التفاصيل البيبلوغرافية
| العنوان: |
Effectiveness of Stereotactic Radiotherapy and Bevacizumab for Recurrent High-Grade Gliomas: A Potential Therapy for Isocitrate Dehydrogenase Wild-Type Recurrent High-Grade Gliomas. |
| المؤلفون: |
Yasuda, Takayuki1, Muragaki, Yoshihiro1,2 ymuragaki@twmu.ac.jp, Nitta, Masayuki1,2, Miyamoto, Kazunari3, Oura, Yuko3, Henmi, Takuo4, Noguchi, Sanshiro4, Oda, Hideaki4, Saito, Taiichi1, Maruyama, Takashi1,2, Atsuchi, Shoko5, Miura, Naohisa5, Kawamata, Takakazu1 |
| المصدر: |
World Neurosurgery. Jun2018, Vol. 114, pe1138-e1146. 1p. |
| مصطلحات موضوعية: |
*GLIOMA treatment, *RADIOTHERAPY, *BEVACIZUMAB, *TEMOZOLOMIDE, *CANCER chemotherapy, *THERAPEUTICS |
| مستخلص: |
Objective This study aimed to evaluate the efficacy of stereotactic radiotherapy combined with bevacizumab (SRT-Bv) compared with Bv treatment for recurrent high-grade gliomas (HGGs). Methods Data for patients with recurrent HGGs who received SRT and Bv ( n = 29) or Bv ( n = 29) between June 2014 and September 2016 were retrospectively analyzed. All patients received conventional radiotherapy (total, 60 Gy) before this study. SRT was administered at a median dose of 42 Gy in 3–7 fractions. The recurrence pattern was classified into 3 groups: in-field, marginal, and out-field. Results The median overall survival in the SRT-Bv group was significantly longer than that in the Bv group (10.4 vs. 5.6 months; P = 0.02). In patients with isocitrate dehydrogenase wild-type tumors, the SRT-Bv treatment significantly prolonged survival more than the Bv treatment (10.9 vs. 8.2 months; P = 0.01). The World Health Organization grade and presence or absence of SRT were significant prognostic factors in the univariate analysis. Besides brain edema in 2 cases and asymptomatic subdural hematoma in 1 case, no other severe adverse effect due to SRT-Bv treatment was recorded. The pattern of recurrence was as follows: in-field, 2 cases (7%); marginal, 8 cases (28%); out-field, 11 cases (38%); no recurrence on radiologic findings, 6 cases (21%); and uncertain, 2 cases (7%). Conclusions SRT-Bv treatment significantly prolonged survival duration more than Bv treatment and provides good local control in patients with recurrent HGGs, especially those with isocitrate dehydrogenase wild-type tumors. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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