التفاصيل البيبلوغرافية
| العنوان: |
Ca(II), Sr(II) and Ba(II) ion interaction with the rheumatoid arthritis drug tenoxicam: Structural, thermal, and biological characterization. |
| المؤلفون: |
Adam, Abdel Majid A.1 majidadam@yahoo.com |
| المصدر: |
Applied Organometallic Chemistry. Feb2018, Vol. 32 Issue 2, p1-1. 11p. |
| مصطلحات موضوعية: |
*RHEUMATOID arthritis, *TREATMENT of arthritis, *NONSTEROIDAL anti-inflammatory agents, *TEMAZEPAM, *METAL complexes, *METAL ions, *STOICHIOMETRY, *CELL growth, *THERAPEUTICS |
| مستخلص: |
Recently, one of the most common conditions that manifests as joint and muscle inflammation is rheumatoid arthritis. One of the treatments for this arthritis includes non‐steroidal anti‐inflammatory drugs (NSAIDs) of the oxicam family, and the widest used drug in this family is tenoxicam (Tenox). In this study, the complexation properties of the drug Tenox with Ca(II), Sr(II) and Ba(II) ions in a (dichloromethane + water) binary solvent system are reported. The formed metal complexes were characterized structurally, thermally, and biologically. Tenox was found to act as a chelate monoanionic ligand towards all metal ions with complexation stoichiometry of 1:2 (Metal: Tenox) for Ca(II) and Sr(II) ions, and 1:1 for Ba(II) ions. The Tenox ligand behaves as a bidentate ligand when coordinated with Sr(II) or Ba(II) ions and as a tridentate ligand when coordinated with Ca(II) ions. The Sr(II) and Ba(II) complex of the Tenox ligand exhibited marked inhibitory effect on the cell growth of the C. albicans species. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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