التفاصيل البيبلوغرافية
| العنوان: |
Regulation of Neurospora crassa cell wall remodeling via the cot- 1 pathway is mediated by gul- 1. |
| المؤلفون: |
Herold, Inbal1, Yarden, Oded1 Oded.Yarden@mail.huji.ac.il |
| المصدر: |
Current Genetics. Feb2017, Vol. 63 Issue 1, p145-159. 15p. |
| مصطلحات موضوعية: |
*NEUROSPORA crassa, *FUNGAL cell walls, *GENE expression, *GENETIC transcription, *CHITIN, *FUNGI |
| مستخلص: |
Impairment of the Neurospora crassa Nuclear DBF2-related kinase-encoding gene cot- 1 results in pleiotropic effects, including abnormally thick hyphal cell walls and septa. An increase in the transcript abundance of genes encoding chitin and glucan synthases and the chitinase gh18- 5, but not the cell wall integrity pathway transcription factor rlm- 1, accompany the phenotypic changes observed. Deletion of chs- 5 or chs- 7 in a cot- 1 background results in a reduction of hyperbranching frequency characteristic of the cot- 1 parent. gul- 1 (a homologue of the yeast SSD1 gene) encodes a translational regulator and has been shown to partially suppress cot- 1. We demonstrate that the high expression levels of the cell wall remodeling genes analyzed is curbed, and reaches near wild type levels, when gul- 1 is inactivated. This is accompanied by morphological changes that include reduced cell wall thickness and restoration of normal chitin levels. We conclude that gul- 1 is a mediator of cell wall remodeling within the cot- 1 pathway. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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