التفاصيل البيبلوغرافية
| العنوان: |
Reduced Histone Expression or a Defect in Chromatin Assembly Induces Respiration. |
| المؤلفون: |
Galdieri, Luciano1, Tiantian Zhang1, Rogerson, Daniella1, Vancura, Ales1 vancuraa@stjohns.edu |
| المصدر: |
Molecular & Cellular Biology. Apr2016, Vol. 36 Issue 7, p1064-1077. 14p. |
| مصطلحات موضوعية: |
*CHROMATIN, *CELL membrane formation, *TRANSCRIPTION factors, *GENOMES, *GENE expression, *HISTONES, *SACCHAROMYCES cerevisiae |
| مستخلص: |
Regulation of mitochondrial biogenesis and respiration is a complex process that involves several signaling pathways and transcription factors as well as communication between the nuclear and mitochondrial genomes. Here we show that decreased expression of histones or a defect in nucleosome assembly in the yeast Saccharomyces cerevisiae results in increased mitochondrial DNA (mtDNA) copy numbers, oxygen consumption, ATP synthesis, and expression of genes encoding enzymes of the tricarboxylic acid (TCA) cycle and oxidative phosphorylation (OXPHOS). The metabolic shift from fermentation to respiration induced by altered chromatin structure is associated with the induction of the retrograde (RTG) pathway and requires the activity of the Hap2/3/4/5p complex as well as the transport and metabolism of pyruvate in mitochondria. Together, our data indicate that altered chromatin structure relieves glucose repression of mitochondrial respiration by inducing transcription of the TCA cycle and OXPHOS genes carried by both nuclear and mitochondrial DNA. [ABSTRACT FROM AUTHOR] |
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