التفاصيل البيبلوغرافية
| العنوان: |
CNTFR Genotype and Sprint/power Performance: Case-control Association and Functional Studies. |
| المؤلفون: |
Miyamoto-Mikami, E.1 eri-m.d925@y.fuji.waseda.jp, Fujita, Y.2, Murakami, H.3, Ito, M.2, Miyachi, M.3, Kawahara, T.4, Fuku, N.5 |
| المصدر: |
International Journal of Sports Medicine. 2016, Vol. 37 Issue 5, p411-417. 7p. |
| مصطلحات موضوعية: |
*ANALYSIS of covariance, *CHI-squared test, *JAPANESE people, *STATISTICS, *T-test (Statistics), *DATA analysis, *ELITE athletes, *CILIARY neurotrophic factor, *GENOTYPES |
| مستخلص: |
T he aim of this study was to investigate whether rs41274853 in the 3'-untranslated region of the ciliary neurotrophic factor receptor gene (CNTFR) is associated with elite sprint/power athletic status and assess its functional significance. A total of 211 Japanese sprint/power track and field athletes (62 international, 72 national, and 77 regional athletes) and 814 Japanese controls were genotyped at rs41274853. Luciferase reporter assay was conducted to investigate whether this C-to-T polymorphism affects binding of microRNA miR-675-5p to this region. The TT genotype was significantly more frequent among international sprint/power athletes (19.4 %) than in the controls after Bonferroni correction (7.9 %, P = 0.036, OR = 2.81 [95 % CI: 1.43-- 5.55]). Furthermore, in non-athletic young/ middle-aged men (n = 132), TT genotype carriers exhibited significantly greater leg extension power (26.6 ± 5.4 vs. 24.0 ± 5.4 W/kg BW, P = 0.019) and vertical jump performance (50.1 ± 6.9 vs. 47.9 ± 7.5 cm, P = 0.047) than the CC + CT genotype carriers. Reporter assays revealed that the miR- 675-5p binds to this polymorphic region within the CNTFR mRNA, irrespective of the rs41274853 allele present. Although the functional signifi- cance of the rs41274853 polymorphism remains unclear, the CNTFR is one of the candidate genes contributing to sprint/power performance. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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