التفاصيل البيبلوغرافية
| العنوان: |
Differential effects of co-administration of oxotremorine with SCH 23390 on impulsive choice in high-impulsive rats and low-impulsive rats. |
| المؤلفون: |
Tian, Lin1, Qin, Xingna1, Sun, Jinling1, Li, Xinwang1 lixw701@sina.cn, Wei, Li2 18930173636@189.cn |
| المصدر: |
Pharmacology, Biochemistry & Behavior. Mar2016, Vol. 142, p56-63. 8p. |
| مصطلحات موضوعية: |
*OXOTREMORINE, *DRUG administration, *IMPULSIVE personality, *LABORATORY rats, *ACETYLCHOLINE, *DOPAMINERGIC mechanisms |
| مستخلص: |
The effect of acetylcholine on impulsive choice is thought to be due to interactions between cholinergic and dopaminergic systems, but this hypothesis has not been proven. This study investigated whether D 1 -like receptors were involved in the effects of the muscarinic cholinergic agonist oxotremorine on impulsive choice in high-impulsive rats (HI rats, n = 8) and low-impulsive rats (LI rats, n = 8) characterized by basal levels of impulsive choice in a delay-discounting task. The results revealed that oxotremorine (0.05 mg/kg) significantly increased the choice of the large reinforcer in HI rats, whereas decreased the choice of the large reinforcer in LI rats. The D 1 -like antagonist SCH 23390 produced significant reductions in the large-reinforcer choice in HI rats (0.01 mg/kg) and LI rats (0.005, 0.0075, and 0.01 mg/kg). SCH 23390 significantly inhibited the increase in the choice of the large reinforcer induced by oxotremorine (0.05 mg/kg) in HI rats at doses of 0.005 and 0.0075 mg/kg, but enhanced the effect of oxotremorine in LI rats only at the dose of 0.0075 mg/kg. These findings suggested that D 1 -like receptors might be involved in the differential effects of oxotremorine on impulsive choice between HI rats and LI rats. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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