التفاصيل البيبلوغرافية
| العنوان: |
Correction of Retrograde Ejaculation in Patients with Diabetes Mellitus Using Endourethral Collagen Injection: Preliminary Results. |
| المؤلفون: |
Kurbatov, Dmitry1, Russo, Giorgio Ivan2 giorgioivan@virgilio.it, Galstyan, G. R.1, Rozhivanov, Roman1, Lepetukhin, Alexander1, Dubsky, Sergey1, Shwartz, Y. G.1, Cimino, Sebastiano2, Morgia, Giuseppe2, Sansalone, Salvatore3 |
| المصدر: |
Journal of Sexual Medicine. Nov2015, Vol. 12 Issue 11, p2126-2129. 4p. |
| مصطلحات موضوعية: |
*EJACULATION, *TYPE 1 diabetes, *PHYSIOLOGICAL effects of collagen, *BECK Depression Inventory, *INFERTILITY, *PARASYMPATHETIC nervous system |
| مستخلص: |
Introduction: Diabetic neuropathy secondary to diabetes mellitus type 1 (DM1) is responsible for retrograde ejaculation (RE) in 5-18% of cases. Medical treatment of RE is based either on increasing the sympathetic tone of the bladder or on decreasing the parasympathetic activity. However, the onset of side effects and the lack of response should be considered. Aims. The aim of this study was to analyze long-term outcome of endourethral injection of volume-forming material (VFM) of collagen type 2 into bladder neck submucosa in patients with RE secondary to DM1. Methods: Twenty-four patients with complete RE refractory to imipramine and DM1 were included in the study. Patients were single-blinded randomized according to a computer-generated random sequence with a 1:1 ratio in two treatment groups, namely group A (endourethral collage type 2 injection) and group B (endourethral saline water injection). New technique includes an endoscopic injection of VFM such as collagen (Correcting MIT®, Ltd. minimally invasive technologies, Moscow, Russia) into bladder neck submucosa. Primary endpoint of the study was the reduction of semen antegrade volume (mL). Secondary endpoints were considered as the changes of antegrade count (millions/mL), antegrade total motility (%), antegrade progressive motility (%), State-Trait Anxiety Inventory, Beck Depression Questionnaire and International Index of Erectile Function (IIEF-5). Pregnancy rate was calculated in each group. Results: Twenty-three patients completed the study. In group A, significant differences from baseline to 12 months were observed relative to antegrade volume (mL) (mean difference: 0.71, P < 0.05), antegrade count (millions/mL) (mean difference: 45.6, P < 0.05), antegrade total motility (%) (mean difference: 15.4, P < 0.05) and antegrade progressive motility (%) (mean difference: 8.4, P < 0.05). In group A, we observed significant differences in terms State-Trait Anxiety Inventory (mean difference: −20.5, P < 0.05) and Beck Depression Inventory (mean difference: −8.4, P < 0.05) with significant differences compared with group B.We observed significant improvements in group A vs. group B when considering primary and secondary endpoints of the study, but not for the IIEF-5. Conclusion. Correction of RE in DM1 patients could be achieved with endourethral injection of collagen type 2. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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