التفاصيل البيبلوغرافية
| العنوان: |
Application of 3D NMR for Structure Determination of Peptide Natural Products. |
| المؤلفون: |
Fan Zhang1, Adnani, Navid1, Vazquez-Rivera, Emmanuel2, Braun, Doug R.1, Tonelli, Marco3, Andes, David R.4, Bugni, Tim S.1 tim.bugni@wisc.edu |
| المصدر: |
Journal of Organic Chemistry. 9/4/2015, Vol. 80 Issue 17, p8713-8719. 7p. |
| مصطلحات موضوعية: |
*CHEMICAL structure, *NUCLEAR magnetic resonance, *ANTIBIOTICS, *THREE-dimensional imaging, *PEPTIDES |
| مستخلص: |
Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
