التفاصيل البيبلوغرافية
| العنوان: |
Interference with acute nausea and anticipatory nausea in rats by fatty acid amide hydrolase (FAAH) inhibition through a PPARα and CB receptor mechanism, respectively: a double dissociation. |
| المؤلفون: |
Rock, Erin1, Limebeer, Cheryl1, Ward, Jordan1, Cohen, Arianne1, Grove, Katherine1, Niphakis, Micah2, Cravatt, Benjamin2, Parker, Linda1 parkerl@uoguelph.ca |
| المصدر: |
Psychopharmacology. Oct2015, Vol. 232 Issue 20, p3841-3848. 8p. 3 Graphs. |
| مصطلحات موضوعية: |
*ANTICIPATORY nausea & vomiting, *FATTY acids, *HYDROLASES, *PEROXISOME proliferator-activated receptors, *ENZYME inhibitors, *CANNABINOID receptors, *LABORATORY rats, *THERAPEUTICS |
| مستخلص: |
Rationale: Fatty acid amide hydrolase (FAAH) inhibition elevates anandamide (AEA), which acts on cannabinoid (CB and CB) receptors, as well as N-palmitoylethanolamide (PEA) and N-oleoylethanolamine (OEA), which act on peroxisome proliferator-activated receptor alpha (PPARα). Here, we determine the mechanism of action of FAAH inhibition on acute and anticipatory nausea (AN). Objective: We compared the effectiveness and mechanism of action of two FAAH inhibitors, URB597 and PF-3845, to reduce acute nausea and AN in rodent models of conditioned gaping. Materials and methods: For assessment of acute nausea, rats were pretreated with vehicle (VEH), URB597 (0.3 and 10 mg/kg, experiment 1a) or PF-3845 (10 mg/kg, experiment 1b) 120 min prior to a saccharin-lithium chloride (LiCl) pairing. To assess the CB receptor or PPARα mediation of the effect of PF-3845 on acute nausea, rats were also pretreated with rimonabant or MK886, respectively. For assessment of AN, following four pairings of a novel context with LiCl, rats received a pretreatment of VEH, URB597 (0.3 mg/kg, experiment 2a), or PF-3845 (10, 20 mg/kg, experiment 2b) 120 min prior to placement in the AN context. To assess the CB receptor or PPARα mediation of the effect, rats were also pretreated with rimonabant or MK886, respectively. Results: PF-3845 (10 mg/kg, but not URB597 0.3 or 10 mg/kg) suppressed acute nausea via PPARα, but not CB receptors. URB597 (0.3 and 10 mg/kg) or PF-3845 (10 and 20 mg/kg) reduced AN via CB receptors, but not PPARα. Conclusions: FAAH inhibition reduces acute nausea and AN through PPARα and CB receptor mediated effects, respectively. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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