التفاصيل البيبلوغرافية
| العنوان: |
Mechanisms of the age-associated deterioration in glucose tolerance: contribution of alterations in insulin secretion, action, and clearance. |
| المؤلفون: |
Basu R (AUTHOR), Breda E (AUTHOR), Oberg AL (AUTHOR), Powell CC (AUTHOR), Man CD (AUTHOR), Basu A (AUTHOR), Vittone JL (AUTHOR), Klee GG (AUTHOR), Arora P (AUTHOR), Jensen MD (AUTHOR), Toffolo G (AUTHOR), Cobelli C (AUTHOR), Rizza RA (AUTHOR), Basu, Rita1 (AUTHOR), Breda, Elena (AUTHOR), Oberg, Ann L (AUTHOR), Powell, Claudia C (AUTHOR), Dalla Man, Chiara (AUTHOR), Basu, Ananda (AUTHOR), Vittone, Janet L (AUTHOR) |
| المصدر: |
Diabetes. Jul2003, Vol. 52 Issue 7, p1738-1748. 11p. |
| مستخلص: |
Glucose tolerance decreases with age. For determining the cause of this decrease, 67 elderly and 21 young (70.1 +/- 0.7 vs. 23.7 +/- 0.8 years) participants ingested a mixed meal and received an intravenous injection of glucose. Fasting glucose and the glycemic response above basal were higher in the elderly than in the young participants after either meal ingestion (P < 0.001) or glucose injection (P < 0.01). Insulin action (Si), measured with the meal and intravenous glucose tolerance test models, was highly correlated (r = 0.72; P < 0.001) and lower (P
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| قاعدة البيانات: |
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