The Extended Clearance Model

التفاصيل البيبلوغرافية
العنوان:	The Extended Clearance Model
المؤلفون:	Poller, Birk, Huth, Felix, Kastrinou‐Lampou, Vlasia, Kullak‐Ublick, Gerd A, Arand, Michael, Camenisch, Gian
المساهمون:	Li, Albert P, Li, A P ( Albert P )
المصدر:	Poller, Birk; Huth, Felix; Kastrinou‐Lampou, Vlasia; Kullak‐Ublick, Gerd A; Arand, Michael; Camenisch, Gian (2021). The Extended Clearance Model. In: Li, Albert P. Transporters and Drug-Metabolizing Enzymes in Drug Toxicity. Hoboken, New Jersey: John Wiley & Sons, 455-479.
بيانات النشر:	John Wiley & Sons
سنة النشر:	2021
المجموعة:	University of Zurich (UZH): ZORA (Zurich Open Repository and Archive
مصطلحات موضوعية:	Institute of Pharmacology and Toxicology, Clinic for Clinical Pharmacology and Toxicology, 570 Life sciences, biology, 610 Medicine & health
الوصف:	Cell stress perturbations in the liver are frequently the result of inhibitory insults on hepatic enzyme- and/or transporter-mediated processes involved in the disposition of bile acids and/or bilirubin. Hence, in recent years, more or less complex drug–drug interaction (DDI) prediction techniques (so-called R-value models) were derived to anticipate the overall drug-induced liver injury (DILI) risk of new chemical entities. This article aims to provide an integrated overview of our latest in-house efforts to forecast quantitatively, cell stress-based DILI predominantly by integrating principles of the extended clearance model (ECM).
نوع الوثيقة:	book part
اللغة:	English
ردمك:	978-1-119-17084-6 1-119-17084-2
العلاقة:	https://www.zora.uzh.ch/223030Test; urn:isbn:978-1-119-17084-6
DOI:	10.1002/9781119171003.ch15
الإتاحة:	https://doi.org/10.1002/9781119171003.ch15Test https://www.zora.uzh.ch/id/eprint/223030Test/ https://www.zora.uzh.ch/223030Test
حقوق:	info:eu-repo/semantics/closedAccess
رقم الانضمام:	edsbas.3F1569F7
قاعدة البيانات:	BASE

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الوصف
ردمك:	9781119170846 1119170842
DOI:	10.1002/9781119171003.ch15