دورية أكاديمية
Ophthalmic Biomarkers for Alzheimer’s Disease: A Review
العنوان: | Ophthalmic Biomarkers for Alzheimer’s Disease: A Review |
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المؤلفون: | Ayesha Majeed, Ben Marwick, Haoqing Yu, Hassan Fadavi, Mitra Tavakoli |
المصدر: | Frontiers in Aging Neuroscience, Vol 13 (2021) |
بيانات النشر: | Frontiers Media S.A., 2021. |
سنة النشر: | 2021 |
المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
مصطلحات موضوعية: | neurodegenerative disease, Alzheimer’s disease, ophthalmic biomarker, oculomics, ophthalmic imaging, dementia, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
الوصف: | Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by neuronal loss, extracellular amyloid-β (Aβ) plaques, and intracellular neurofibrillary tau tangles. A diagnosis is currently made from the presenting symptoms, and the only definitive diagnosis can be done post-mortem. Over recent years, significant advances have been made in using ocular biomarkers to diagnose various neurodegenerative diseases, including AD. As the eye is an extension of the central nervous system (CNS), reviewing changes in the eye’s biology could lead to developing a series of non-invasive, differential diagnostic tests for AD that could be further applied to other diseases. Significant changes have been identified in the retinal nerve fiber layer (RNFL), cornea, ocular vasculature, and retina. In the present paper, we review current research and assess some ocular biomarkers’ accuracy and reliability that could potentially be used for diagnostic purposes. Additionally, we review the various imaging techniques used in the measurement of these biomarkers. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1663-4365 |
العلاقة: | https://www.frontiersin.org/articles/10.3389/fnagi.2021.720167/fullTest; https://doaj.org/toc/1663-4365Test |
DOI: | 10.3389/fnagi.2021.720167 |
الوصول الحر: | https://doaj.org/article/acf9d12455974eba8f3d6caf122134f0Test |
رقم الانضمام: | edsdoj.f9d12455974eba8f3d6caf122134f0 |
قاعدة البيانات: | Directory of Open Access Journals |
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