دورية أكاديمية
Unexpected Cardiotoxicity in Patients With HER2-Mutant NSCLC Treated With Trastuzumab Deruxtecan: A Case Report
| العنوان: | Unexpected Cardiotoxicity in Patients With HER2-Mutant NSCLC Treated With Trastuzumab Deruxtecan: A Case Report |
|---|---|
| المؤلفون: | Mariona Riudavets, MD, PhD, Arshid Azarine, MD, MSc, Sondes Smaali, MD, Young-Wouk Kim, MD, Vincent Thomas de Montpréville, MD, Alina Miruna Grecea, MD, Charles Naltet, MD, Annas Gazzah, MD, David Planchard, MD, PhD |
| المصدر: | JTO Clinical and Research Reports, Vol 3, Iss 12, Pp 100432- (2022) |
| بيانات النشر: | Elsevier, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| مصطلحات موضوعية: | Non–small cell lung cancer, HER2 mutation, Antibody drug conjugates, Trastuzumab deruxtecan, Cardiotoxicity: Case Report, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| الوصف: | Antibody-drug conjugates targeting receptor tyrosine-protein kinase erbB-2 (ERBB2, HER2) have emerged as promising targeted options for HER2-mutant NSCLC. Among antibody-drug conjugates targeting HER2, trastuzumab deruxtecan was found to have the most impressive efficacy and is a potential new standard of care. Drug-related interstitial lung disease remains a serious unpredictable identified risk for patients treated with trastuzumab deruxtecan, requiring careful monitoring and multidisciplinary management. We report the first two cases of drug-related cardiotoxicity with acute myocarditis that developed after the first trastuzumab deruxtecan cycle. Routine cardiovascular risk screening is advisable, with close collaboration between cardiology specialists and oncologists. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2666-3643 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2666364322001564Test; https://doaj.org/toc/2666-3643Test |
| DOI: | 10.1016/j.jtocrr.2022.100432 |
| الوصول الحر: | https://doaj.org/article/f9a04cb6b8234e7793c0570ef7f55d89Test |
| رقم الانضمام: | edsdoj.f9a04cb6b8234e7793c0570ef7f55d89 |
| قاعدة البيانات: | Directory of Open Access Journals |
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