دورية أكاديمية
Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control
العنوان: | Increased sLRP1 and decreased atrial natriuretic peptide plasma levels in newly diagnosed T2DM patients are normalized after optimization of glycemic control |
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المؤلفون: | Eduardo García, Pedro Gil, Inka Miñambres, Aleyda Benitez-Amaro, Claudia Rodríguez, Lene Claudi, Josep Julve, Sonia Benitez, Jose Luís Sánchez-Quesada, Jose Rives, Xavier Garcia-Moll, David Vilades, Antonio Perez, Vicenta Llorente-Cortes |
المصدر: | Frontiers in Endocrinology, Vol 14 (2023) |
بيانات النشر: | Frontiers Media S.A., 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
مصطلحات موضوعية: | sLRP1, ANP, metabolic control, T2DM, hypoglycemic treatments, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
الوصف: | BackgroundLow-density lipoprotein receptor-related protein 1 (LRP1) negatively modulates circulating atrial natriuretic peptide (ANP) levels. Both molecules are involved in the regulation of cardiometabolism.ObjectivesTo evaluate soluble LRP1 (sLRP1) and ANP levels in people with newly diagnosed type 2 diabetes mellitus (T2DM) and determine the effects of metabolic optimization.MethodsThis single-center longitudinal observational study recruited patients with newly diagnosed T2DM (n = 29, HbA1c > 8.5%), and 12 healthy control, age- and sex-matched volunteers. sLRP1 and ANP levels were measured by immunoassays at T2DM onset and at one year after optimization of glycemic control (HbA1c ≤ 6.5%).ResultsT2DM had higher sLRP1 levels than the control group (p = 0.014) and lower ANP levels (p =0.002). At 12 months, 23 T2DM patients reached the target of HbA1c ≤ 6.5%. These patients significantly reduced sLRP1 and increased ANP levels. Patients who did not achieve HbA1c < 6.5% failed to normalize sLRP1 and ANP levels. There was an inverse correlation in the changes in sLRP1 and ANP (p = 0.031). The extent of sLRP1 changes over 12 months of metabolic control positively correlated with those of total cholesterol, LDL cholesterol, TG, TG/HDLc, and apolipoprotein B.ConclusionsNewly diagnosed T2DM patients have an increased sLRP1/ANP ratio, and increased sLRP1 and decreased ANP levels are normalized in the T2DM patients that reached an strict glycemic and metabolic control. sLRP1/ANP ratio could be a reliable marker of cardiometabolic function. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-2392 |
العلاقة: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1236487/fullTest; https://doaj.org/toc/1664-2392Test |
DOI: | 10.3389/fendo.2023.1236487 |
الوصول الحر: | https://doaj.org/article/f98249e19b39477e823a3127f88d3ec8Test |
رقم الانضمام: | edsdoj.f98249e19b39477e823a3127f88d3ec8 |
قاعدة البيانات: | Directory of Open Access Journals |