دورية أكاديمية
Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics
العنوان: | Fighting type 2 diabetes: Formulation strategies for peptide-based therapeutics |
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المؤلفون: | Carlos Bendicho-Lavilla, Iria Seoane-Viaño, Francisco J. Otero-Espinar, Asteria Luzardo-Álvarez |
المصدر: | Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 621-636 (2022) |
بيانات النشر: | Elsevier, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Therapeutics. Pharmacology |
مصطلحات موضوعية: | Type 2 diabetes mellitus, Glucagon-like peptide-1 receptor agonists, Exenatide, Subcutaneous administration, Amylin mimetics, Drug delivery systems, Therapeutics. Pharmacology, RM1-950 |
الوصف: | Diabetes mellitus is a major health problem with increasing prevalence at a global level. The discovery of insulin in the early 1900s represented a major breakthrough in diabetes management, with further milestones being subsequently achieved with the identification of glucagon-like peptide-1 (GLP-1) and the introduction of GLP-1 receptor agonists (GLP-1 RAs) in clinical practice. Moreover, the subcutaneous delivery of biotherapeutics is a well-established route of administration generally preferred over the intravenous route due to better patient compliance and prolonged drug absorption. However, current subcutaneous formulations of GLP-1 RAs present pharmacokinetic problems that lead to adverse reactions and treatment discontinuation. In this review, we discuss the current challenges of subcutaneous administration of peptide-based therapeutics and provide an overview of the formulations available for the different routes of administration with improved bioavailability and reduced frequency of administration. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2211-3835 |
العلاقة: | http://www.sciencedirect.com/science/article/pii/S2211383521002811Test; https://doaj.org/toc/2211-3835Test |
DOI: | 10.1016/j.apsb.2021.08.003 |
الوصول الحر: | https://doaj.org/article/f28647d19b144ce6b8790e1aac6f6954Test |
رقم الانضمام: | edsdoj.f28647d19b144ce6b8790e1aac6f6954 |
قاعدة البيانات: | Directory of Open Access Journals |
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