دورية أكاديمية
Modulation of Gut Microbiota and Neuroprotective Effect of a Yeast-Enriched Beer
العنوان: | Modulation of Gut Microbiota and Neuroprotective Effect of a Yeast-Enriched Beer |
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المؤلفون: | Valentina Cecarini, Olee Gogoi, Laura Bonfili, Iolanda Veneruso, Giada Pacinelli, Sara De Carlo, Federica Benvenuti, Valeria D’Argenio, Mauro Angeletti, Nazzareno Cannella, Anna Maria Eleuteri |
المصدر: | Nutrients, Vol 14, Iss 12, p 2380 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Nutrition. Foods and food supply |
مصطلحات موضوعية: | beer, Alzheimer’s disease, amyloid, inflammation, microbiota, Nutrition. Foods and food supply, TX341-641 |
الوصف: | Beer is the most consumed alcoholic beverage worldwide. It is rich in nutrients, and with its microbial component it could play a role in gut microbiota modulation. Conflicting data are currently available regarding the consequences of alcohol and alcohol-containing beverages on dementia and age-associated disorders including Alzheimer’s disease (AD), a neurodegeneration characterized by protein aggregation, inflammatory processes and alterations of components of the gut–brain axis. The effects of an unfiltered and unpasteurized craft beer on AD molecular hallmarks, levels of gut hormones and composition of micro/mycobiota were dissected using 3xTg-AD mice. In addition, to better assess the role of yeasts, beer was enriched with the same Saccharomyces cerevisiae strain used for brewing. The treatment with the yeast-enriched beer ameliorated cognition and favored the reduction of Aβ(1-42) and pro-inflammatory molecules, also contributing to an increase in the concentration of anti-inflammatory cytokines. A significant improvement in the richness and presence of beneficial taxa in the gut bacterial population of the 3xTg-AD animals was observed. In addition, the fungal order, Sordariomycetes, associated with gut inflammatory conditions, noticeably decreased with beer treatments. These data demonstrate, for the first time, the beneficial effects of a yeast-enriched beer on AD signs, suggesting gut microbiota modulation as a mechanism of action. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2072-6643 |
العلاقة: | https://www.mdpi.com/2072-6643/14/12/2380Test; https://doaj.org/toc/2072-6643Test |
DOI: | 10.3390/nu14122380 |
الوصول الحر: | https://doaj.org/article/b91c789f100d46ee9216f4d897ea55f6Test |
رقم الانضمام: | edsdoj.b91c789f100d46ee9216f4d897ea55f6 |
قاعدة البيانات: | Directory of Open Access Journals |
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