دورية أكاديمية
Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy
| العنوان: | Feasibility and tolerability of multimodal peripheral electrophysiological techniques in a cohort of patients with spinal muscular atrophy |
|---|---|
| المؤلفون: | Leandra A.A. Ros, Boudewijn T.H.M. Sleutjes, Diederik J.L. Stikvoort García, H. Stephan Goedee, Fay-Lynn Asselman, Leonard H. van den Berg, W. Ludo van der Pol, Renske I. Wadman |
| المصدر: | Clinical Neurophysiology Practice, Vol 8, Iss , Pp 123-131 (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | Spinal muscular atrophy, Electrophysiological techniques, Feasibility, Tolerability, Numeric rating scale, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | Objective: Electrophysiological techniques are emerging as an aid in identifying prognostic or therapeutic biomarkers in patients with spinal muscular atrophy (SMA), but electrophysiological assessments may be burdensome for patients. We, therefore, assessed feasibility and tolerability of multimodal peripheral non-invasive electrophysiological techniques in a cohort of patients with SMA. Methods: We conducted a single center, longitudinal cohort study investigating the feasibility and tolerability of applying multimodal electrophysiological techniques to the median nerve unilaterally. Techniques consisted of the compound muscle action potential scan, motor nerve excitability tests, repetitive nerve stimulation and sensory nerve action potential. We assessed tolerability using the numeric rating scale (NRS), ranging from 0 (no pain) to 10 (worst possible pain), and defined the protocol to be tolerable if the NRS score ≤ 3. The protocol was considered feasible if it could be performed according to test and quality standards. Results: We included 71 patients with SMA types 1–4 (median 39 years; range 13–67) and 63 patients at follow-up. The protocol was feasible in 98% of patients and was well-tolerated in up to 90% of patients. Median NRS score was 2 (range 0–6 at baseline and range 0–4 at follow-up (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2467-981X |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2467981X23000161Test; https://doaj.org/toc/2467-981XTest |
| DOI: | 10.1016/j.cnp.2023.06.001 |
| الوصول الحر: | https://doaj.org/article/db3b77b3bb4d4bf9aa63de999e1d3536Test |
| رقم الانضمام: | edsdoj.b3b77b3bb4d4bf9aa63de999e1d3536 |
| قاعدة البيانات: | Directory of Open Access Journals |
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