دورية أكاديمية

Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony

التفاصيل البيبلوغرافية
العنوان: Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony
المؤلفون: Monecke, Stefan, Ruppelt-Lorz, Antje, Müller, Elke, Reissig, Annett, Thürmer, Alexander, Shore, Anna C., Coleman, David C., Ehricht, Ralf, Jatzwauk, Lutz
المصدر: GMS Hygiene and Infection Control, Vol 12, p Doc19 (2017)
بيانات النشر: German Medical Science GMS Publishing House, 2017.
سنة النشر: 2017
المجموعة: LCC:Medicine
LCC:Public aspects of medicine
LCC:Microbiology
مصطلحات موضوعية: methicillin-resistant Staphylococcus aureus, MRSA, mupirocin, high-level mupirocin resistance, mupA, “Barnim Epidemic Strain”, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502
الوصف: Mupirocin is used for eradicating methicillin-resistant (MRSA) in nasal colonization. A plasmid-borne gene, , is associated with high-level mupirocin resistance. Despite the fact that, among all MRSA from a tertiary care center in the German state of Saxony, the prevalence of , encoding high-level mupirocin resistance, was approximately 1% over a 15-year period from 2000–2015, a sharp increase to nearly 20% was observed in 2016/2017. DNA microarray profiling revealed that this was due to the dissemination of a variant of CC22-MRSA-IV (“Barnim Epidemic Strain” or “UK-EMRSA-15”), which, in addition to , harbors , , , and – in most isolates – (C). In order to prevent therapy failures and a further spread of this strain, the use of mupirocin should be more stringently controlled as well as guided by susceptibility testing. In addition, MRSA decolonization regimens that rely on other substances, such as betaisodona, polyhexanide or octenidine, should be considered.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: German
English
تدمد: 2196-5226
العلاقة: http://www.egms.de/static/en/journals/dgkh/2017-12/dgkh000304.shtmlTest; https://doaj.org/toc/2196-5226Test
DOI: 10.3205/dgkh000304
الوصول الحر: https://doaj.org/article/9d784aaa3a3246b9a9ff9fde219b59baTest
رقم الانضمام: edsdoj.9d784aaa3a3246b9a9ff9fde219b59ba
قاعدة البيانات: Directory of Open Access Journals
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