دورية أكاديمية
Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment
| العنوان: | Bladder microenvironment actuated proteomotors with ammonia amplification for enhanced cancer treatment |
|---|---|
| المؤلفون: | Hao Tian, Juanfeng Ou, Yong Wang, Jia Sun, Junbin Gao, Yicheng Ye, Ruotian Zhang, Bin Chen, Fei Wang, Weichang Huang, Huaan Li, Lu Liu, Chuxiao Shao, Zhili Xu, Fei Peng, Yingfeng Tu |
| المصدر: | Acta Pharmaceutica Sinica B, Vol 13, Iss 9, Pp 3862-3875 (2023) |
| بيانات النشر: | Elsevier, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Therapeutics. Pharmacology |
| مصطلحات موضوعية: | Swimming proteomotors, Enhanced diffusion, Glutamine synthetase, Ammonia amplification, Biocompatibility, Penetration, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Enzyme-driven micro/nanomotors consuming in situ chemical fuels have attracted lots of attention for biomedical applications. However, motor systems composed by organism-derived organics that maximize the therapeutic efficacy of enzymatic products remain challenging. Herein, swimming proteomotors based on biocompatible urease and human serum albumin are constructed for enhanced antitumor therapy via active motion and ammonia amplification. By decomposing urea into carbon dioxide and ammonia, the designed proteomotors are endowed with self-propulsive capability, which leads to improved internalization and enhanced penetration in vitro. As a glutamine synthetase inhibitor, the loaded l-methionine sulfoximine further prevents the conversion of toxic ammonia into non-toxic glutamine in both tumor and stromal cells, resulting in local ammonia amplification. After intravesical instillation, the proteomotors achieve longer bladder retention and thus significantly inhibit the growth of orthotopic bladder tumor in vivo without adverse effects. We envision that the as-developed swimming proteomotors with amplification of the product toxicity may be a potential platform for active cancer treatment. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-3835 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2211383523000631Test; https://doaj.org/toc/2211-3835Test |
| DOI: | 10.1016/j.apsb.2023.02.016 |
| الوصول الحر: | https://doaj.org/article/992fb807fef647b3aeb031a93f93aeffTest |
| رقم الانضمام: | edsdoj.992fb807fef647b3aeb031a93f93aeff |
| قاعدة البيانات: | Directory of Open Access Journals |
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