دورية أكاديمية
Glycosylphosphatidylinositols: More than just an anchor?
| العنوان: | Glycosylphosphatidylinositols: More than just an anchor? |
|---|---|
| المؤلفون: | Clive Bate, William Nolan, Alun Williams |
| المصدر: | Communicative & Integrative Biology, Vol 9, Iss 2 (2016) |
| بيانات النشر: | Taylor & Francis Group, 2016. |
| سنة النشر: | 2016 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | cholesterol, glycosylphosphatidylinositols, phospholipase A2, sialic acid, Biology (General), QH301-705.5 |
| الوصف: | There is increasing interest in the role of glycosylphosphatidylinositol (GPI) anchors that attach some proteins to cell membranes. Far from being biologically inert, GPIs influence the targeting, intracellular trafficking and function of the attached protein. Our recent paper demonstrated the role of sialic acid on the GPI of the cellular prion protein (PrPC). The “prion diseases” arise following the conversion of PrPC to a disease-associated isoform called PrPSc or “prion”. Our paper showed that desialylated PrPC inhibited PrPSc formation. Aggregated PrPSc creates a signaling platform in the cell membrane incorporating and activating cytoplasmic phospholipase A2 (cPLA2), an enzyme that regulates PrPC trafficking and hence PrPSc formation. The presence of desialylated PrPC caused the dissociation of cPLA2 from PrP-containing platforms, reduced the activation of cPLA2 and inhibited PrPSc production. We concluded that sialic acid contained within the GPI attached to PrPC modifies local membrane microenvironments that are important in PrP-mediated cell signaling and PrPSc formation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1942-0889 19420889 |
| العلاقة: | https://doaj.org/toc/1942-0889Test |
| DOI: | 10.1080/19420889.2016.1149671 |
| الوصول الحر: | https://doaj.org/article/9805540383d643058d99783cb5032a56Test |
| رقم الانضمام: | edsdoj.9805540383d643058d99783cb5032a56 |
| قاعدة البيانات: | Directory of Open Access Journals |
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