دورية أكاديمية
Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions
العنوان: | Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions |
---|---|
المؤلفون: | Mariana Ingold, Victoria de la Sovera, Rosina Dapueto, Paola Hernández, Williams Porcal, Gloria V. López |
المصدر: | Molecules, Vol 27, Iss 6, p 1756 (2022) |
بيانات النشر: | MDPI AG, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Organic chemistry |
مصطلحات موضوعية: | multicomponent reactions, furoxans, green synthesis, nitric oxide donor, antiproliferative activity, Organic chemistry, QD241-441 |
الوصف: | Prostate and bladder cancers are commonly diagnosed malignancies in men. Several nitric oxide donor compounds with strong antitumor activity have been reported. Thus, continuing with our efforts to explore the chemical space around bioactive furoxan moiety, multicomponent reactions were employed for the rapid generation of molecular diversity and complexity. We herein report the use of Ugi and Groebke–Blackburn–Bienaymé multicomponent reactions under efficient, safe, and environmentally friendly conditions to synthesize a small collection of nitric-oxide-releasing molecules. The in vitro antiproliferative activity of the synthesized compounds was measured against two different human cancer cell lines, LNCaP (prostate) and T24 (bladder). Almost all compounds displayed antiproliferative activity against both cancer cell lines, providing lead compounds with nanomolar GI50 values against the cancer bladder cell line with selectivity indices higher than 10. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1420-3049 |
العلاقة: | https://www.mdpi.com/1420-3049/27/6/1756Test; https://doaj.org/toc/1420-3049Test |
DOI: | 10.3390/molecules27061756 |
الوصول الحر: | https://doaj.org/article/97dc12439ec24e82970ca1a3c7ee41b3Test |
رقم الانضمام: | edsdoj.97dc12439ec24e82970ca1a3c7ee41b3 |
قاعدة البيانات: | Directory of Open Access Journals |
ResultId |
1 |
---|---|
Header |
edsdoj Directory of Open Access Journals edsdoj.97dc12439ec24e82970ca1a3c7ee41b3 928 3 Academic Journal academicJournal 928.373779296875 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.97dc12439ec24e82970ca1a3c7ee41b3&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://doaj.org/article/97dc12439ec24e82970ca1a3c7ee41b3 [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=14203049&ISBN=&volume=27&issue=6&date=20220301&spage=1756&pages=1756-1756&title=Molecules&atitle=Greener%20Synthesis%20of%20Antiproliferative%20Furoxans%20via%20Multicomponent%20Reactions&id=DOI:10.3390/molecules27061756 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) ) |
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Mariana+Ingold%22">Mariana Ingold</searchLink><br /><searchLink fieldCode="AR" term="%22Victoria+de+la+Sovera%22">Victoria de la Sovera</searchLink><br /><searchLink fieldCode="AR" term="%22Rosina+Dapueto%22">Rosina Dapueto</searchLink><br /><searchLink fieldCode="AR" term="%22Paola+Hernández%22">Paola Hernández</searchLink><br /><searchLink fieldCode="AR" term="%22Williams+Porcal%22">Williams Porcal</searchLink><br /><searchLink fieldCode="AR" term="%22Gloria+V%2E+López%22">Gloria V. López</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Molecules, Vol 27, Iss 6, p 1756 (2022) ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => MDPI AG, 2022. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2022 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Organic chemistry ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22multicomponent+reactions%22">multicomponent reactions</searchLink><br /><searchLink fieldCode="DE" term="%22furoxans%22">furoxans</searchLink><br /><searchLink fieldCode="DE" term="%22green+synthesis%22">green synthesis</searchLink><br /><searchLink fieldCode="DE" term="%22nitric+oxide+donor%22">nitric oxide donor</searchLink><br /><searchLink fieldCode="DE" term="%22antiproliferative+activity%22">antiproliferative activity</searchLink><br /><searchLink fieldCode="DE" term="%22Organic+chemistry%22">Organic chemistry</searchLink><br /><searchLink fieldCode="DE" term="%22QD241-441%22">QD241-441</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Prostate and bladder cancers are commonly diagnosed malignancies in men. Several nitric oxide donor compounds with strong antitumor activity have been reported. Thus, continuing with our efforts to explore the chemical space around bioactive furoxan moiety, multicomponent reactions were employed for the rapid generation of molecular diversity and complexity. We herein report the use of Ugi and Groebke–Blackburn–Bienaymé multicomponent reactions under efficient, safe, and environmentally friendly conditions to synthesize a small collection of nitric-oxide-releasing molecules. The in vitro antiproliferative activity of the synthesized compounds was measured against two different human cancer cell lines, LNCaP (prostate) and T24 (bladder). Almost all compounds displayed antiproliferative activity against both cancer cell lines, providing lead compounds with nanomolar GI50 values against the cancer bladder cell line with selectivity indices higher than 10. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article ) Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1420-3049 ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://www.mdpi.com/1420-3049/27/6/1756; https://doaj.org/toc/1420-3049 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.3390/molecules27061756 ) Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/97dc12439ec24e82970ca1a3c7ee41b3" linkWindow="_blank">https://doaj.org/article/97dc12439ec24e82970ca1a3c7ee41b3</link> ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.97dc12439ec24e82970ca1a3c7ee41b3 ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.3390/molecules27061756
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[PhysicalDescription] => Array
(
[Pagination] => Array
(
[PageCount] => 1
[StartPage] => 1756
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => multicomponent reactions
[Type] => general
)
[1] => Array
(
[SubjectFull] => furoxans
[Type] => general
)
[2] => Array
(
[SubjectFull] => green synthesis
[Type] => general
)
[3] => Array
(
[SubjectFull] => nitric oxide donor
[Type] => general
)
[4] => Array
(
[SubjectFull] => antiproliferative activity
[Type] => general
)
[5] => Array
(
[SubjectFull] => Organic chemistry
[Type] => general
)
[6] => Array
(
[SubjectFull] => QD241-441
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Greener Synthesis of Antiproliferative Furoxans via Multicomponent Reactions
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Mariana Ingold
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Victoria de la Sovera
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Rosina Dapueto
)
)
)
[3] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Paola Hernández
)
)
)
[4] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Williams Porcal
)
)
)
[5] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Gloria V. López
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 03
[Type] => published
[Y] => 2022
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-print
[Value] => 14203049
)
)
[Numbering] => Array
(
[0] => Array
(
[Type] => volume
[Value] => 27
)
[1] => Array
(
[Type] => issue
[Value] => 6
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Molecules
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |