دورية أكاديمية
Evaluation of Promoter Hypermethylation of Tumor-Suppressor Genes p14 and p16 in Iranian Endometrial Carcinoma Patients
العنوان: | Evaluation of Promoter Hypermethylation of Tumor-Suppressor Genes p14 and p16 in Iranian Endometrial Carcinoma Patients |
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المؤلفون: | Mina Azizi, Golnaz Asaadi Tehrani |
المصدر: | Middle East Journal of Cancer, Vol 8, Iss 4, Pp 179-186 (2017) |
بيانات النشر: | Shiraz University of Medical Sciences, 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | Endometrial cancer, Epigenetic, p14ARF, p16INK4a, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Background: Endometrial cancer is a common gynecological malignancy with good prognosis in the early stages of the disease. The CpG island in the promoter region of tumor-suppressor genes are frequently methylated in various types of human cancers. In the present study, we have examined the methylation status of the p16INK4a and p14ARF genes in endometrial cancer and healthy endometrium with the aim to identify correlations between promoter hypermethylation, disease risk, and clinicopathological parameters. Methods: We collected 28 formalin fixed paraffin embedded samples and 26 blood samples from endometrial cancer patients and 22 controls. Methylation-specific PCR was applied to analyze the promoter methylation status of the p16INK4a and p14ARF genes in the studied population. The results were analyzed with SPSS software version 20. Results: There was a significant difference between the study groups and the presence of promoter CpG hypermethylation status in the p14 (P |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2008-6709 2008-6687 |
العلاقة: | http://mejc.sums.ac.ir/index.php/mejc/article/view/727/322Test; https://doaj.org/toc/2008-6709Test; https://doaj.org/toc/2008-6687Test |
الوصول الحر: | https://doaj.org/article/8f5c6020304b4a2289a94c2db5ba1adaTest |
رقم الانضمام: | edsdoj.8f5c6020304b4a2289a94c2db5ba1ada |
قاعدة البيانات: | Directory of Open Access Journals |
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