دورية أكاديمية
CD4 + helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment
العنوان: | CD4 + helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment |
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المؤلفون: | Xin Lei, Indu Khatri, Tom de Wit, Iris de Rink, Marja Nieuwland, Ron Kerkhoven, Hans van Eenennaam, Chong Sun, Abhishek D. Garg, Jannie Borst, Yanling Xiao |
المصدر: | Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023) |
بيانات النشر: | Nature Portfolio, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | Science |
الوصف: | The presence of classical type 1 dendritic cells (cDC1) positively influences prognosis in cancer, but their intricate networking with the various T cell types found in the tumour microenvironment is not fully appreciated. Here the authors show that cDC1 encounter with CD4+ helper T-cells transforms their gene expression signature, and these “helped” dendritic cells enable the function of anti-tumour cytotoxic T-cells. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2041-1723 |
العلاقة: | https://doaj.org/toc/2041-1723Test |
DOI: | 10.1038/s41467-022-35615-5 |
الوصول الحر: | https://doaj.org/article/c8c7c60050dc41968a22f225d73ae370Test |
رقم الانضمام: | edsdoj.8c7c60050dc41968a22f225d73ae370 |
قاعدة البيانات: | Directory of Open Access Journals |
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