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Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats

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العنوان: Insulin glargine affects the expression of Igf-1r, Insr, and Igf-1 genes in colon and liver of diabetic rats
المؤلفون: Clara I Juárez-Vázquez, Carmen M Gurrola-Díaz, Belinda Vargas-Guerrero, José A Domínguez-Rosales, Jessica Rodriguez-Ortiz, Patricio Barros-Núñez, Silvia E Flores-Martínez, José Sánchez-Corona, Mónica A Rosales-Reynoso
المصدر: Iranian Journal of Basic Medical Sciences, Vol 21, Iss 5, Pp 489-494 (2018)
بيانات النشر: Mashhad University of Medical Sciences, 2018.
سنة النشر: 2018
المجموعة: LCC:Medicine
مصطلحات موضوعية: Colon, Diabetes, Insulin glargine, Liver, Metformin, NPH insulin, Rats, Medicine
الوصف: Objective(s): The mitogenic effect of the analogous insulin glargine is currently under debate since several clinical studies have raised the possibility that insulin glargine treatment has a carcinogenic potential in different tissues. This study aimed to evaluate the Igf-1r, Insr, and Igf-1 gene expression in colon and liver of streptozotocin-induced diabetic rats in response to insulin glargine, neutral protamine Hagedorn (NPH) insulin, and metformin treatments. Materials and Methods: Male Wistar rats were induced during one week with streptozotocin to develop Type 2 Diabetes (T2D) and then randomly distributed into four groups. T2D rats included in the first group received insulin glargine, the second group received NPH insulin, the third group received metformin; finally, untreated T2D rats were included as the control group. All groups were treated for seven days; after the treatment, tissue samples of liver and colon were obtained. Quantitative PCR (qPCR) was performed to analyze the Igf-1r, Insr and Igf-1 gene expression in each tissue sample. Results: The liver tissue showed overexpression of the Insr and Igf-1r genes (P>0.001) in rats treated with insulin glargine in comparison with the control group. Similar results were observed for the Insr gene (P>0.011) in colonic tissue of rats treated with insulin glargine. Conclusion: These observations demonstrate that insulin glargine promote an excess of insulin and IGF-1 receptors in STZ-induced diabetic rats, which could overstimulate the mitogenic signaling pathways.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2008-3866
2008-3874
العلاقة: http://ijbms.mums.ac.ir/article_10542_7e264878e6e9c46dab650b5d7c6bc9c3.pdfTest; https://doaj.org/toc/2008-3866Test; https://doaj.org/toc/2008-3874Test
DOI: 10.22038/ijbms.2018.24867.6185
الوصول الحر: https://doaj.org/article/8065b0f790834f22a8ddb7d3f91fdafeTest
رقم الانضمام: edsdoj.8065b0f790834f22a8ddb7d3f91fdafe
قاعدة البيانات: Directory of Open Access Journals
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