دورية أكاديمية
A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress
العنوان: | A midbrain GABAergic circuit constrains wakefulness in a mouse model of stress |
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المؤلفون: | Shuancheng Ren, Cai Zhang, Faguo Yue, Jinxiang Tang, Wei Zhang, Yue Zheng, Yuanyuan Fang, Na Wang, Zhenbo Song, Zehui Zhang, Xiaolong Zhang, Han Qin, Yaling Wang, Jianxia Xia, Chenggang Jiang, Chao He, Fenlan Luo, Zhian Hu |
المصدر: | Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024) |
بيانات النشر: | Nature Portfolio, 2024. |
سنة النشر: | 2024 |
المجموعة: | LCC:Science |
مصطلحات موضوعية: | Science |
الوصف: | Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wakefulness in acute stress conditions have been extensively identified, less is known about the circuit mechanisms constraining wakefulness to prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation of GAD2-positive GABAergic neurons in the midbrain dorsal raphe nucleus (DRNGAD2) decreased wakefulness, while inhibition or ablation of these neurons produced an increase in wakefulness along with hyperactivity. Surprisingly, DRNGAD2 neurons were paradoxically wakefulness-active and were further activated by acute stress. Bidirectional manipulations revealed that DRNGAD2 neurons constrained the increase of wakefulness and arousal level in a mouse model of stress. Circuit-specific investigations demonstrated that DRNGAD2 neurons constrained wakefulness via inhibition of the wakefulness-promoting paraventricular thalamus. Therefore, the present study identified a wakefulness-constraining role DRNGAD2 neurons in acute stress conditions. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2041-1723 |
العلاقة: | https://doaj.org/toc/2041-1723Test |
DOI: | 10.1038/s41467-024-46707-9 |
الوصول الحر: | https://doaj.org/article/7f71d9eab2fc490480d03e1870124b32Test |
رقم الانضمام: | edsdoj.7f71d9eab2fc490480d03e1870124b32 |
قاعدة البيانات: | Directory of Open Access Journals |
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