دورية أكاديمية
Association of cytokines, neurological disability, and disease duration in HAM/TSP patients Associação de citocinas, incapacidade neurológica e duração da doença em pacientes com mielopatia associada ao HTLV-I/paraparesia espástica tropical (MAH/PET)
| العنوان: | Association of cytokines, neurological disability, and disease duration in HAM/TSP patients Associação de citocinas, incapacidade neurológica e duração da doença em pacientes com mielopatia associada ao HTLV-I/paraparesia espástica tropical (MAH/PET) |
|---|---|
| المؤلفون: | André Luiz Muniz, Waldyr Rodrigues Jr., Silvane B. Santos, Amélia R. de Jesus, Aurélia F. Porto, Néviton Castro, Jamary Oliveira-Filho, Juliana Passos Almeida, Otávio Moreno-Carvalho, Edgar M. Carvalho |
| المصدر: | Arquivos de Neuro-Psiquiatria, Vol 64, Iss 2a, Pp 217-221 (2006) |
| بيانات النشر: | Academia Brasileira de Neurologia (ABNEURO), 2006. |
| سنة النشر: | 2006 |
| المجموعة: | LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| مصطلحات موضوعية: | vírus 1 linfotrópico T humano, doenças do sistema nervoso, citocinas, incapacidade neurológica, human T-lymphotropic virus 1, nervous system diseases, cytokines, neurological disability, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| الوصف: | OBJECTIVE: To identify clinical and immunological markers associated with HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP). METHOD: 237 HTLV-I infected individuals were clinically assessed. They were classified according to the Expanded Disability Status Scale (EDSS) and Osame’s Motor Disability Score (OMDS). Cytokine levels were determined in HTLV-I seropositive individuals. RESULTS: 37 patients had HAM/TSP. There was a correlation between the degrees of disability assessed by both scales. There was also a correlation between the duration of HAM/TSP and the severity of disability assessed by either EDSS or OMDS. Higher levels of IFN-gamma were detected in unstimulated peripheral blood mononuclear cells (PBMC) from HAM/TSP patients as compared with HTLV-I carriers. CONCLUSION: This study shows the validity of the neurological scales to classify the degree of neurological disability in HTLV-I carriers and suggests a progressive behavior of HAM/TSP. This study also shows that IFN-gamma in PBMC supernatants are markers of HAM/TSP.OBJETIVO: Identificar marcadores clínicos e imunológicos associados com a mielopatia associada ao HTLV-I/paraparesia espástica tropical (MAH/PET). MÉTODO: 237 indivíduos infectados pelo HTLV-I foram clinicamente avaliados. Eles foram classificados de acordo com a escala expandida do estado de incapacidade de Kurtzke (EDSS) e escala de incapacidade motora de Osame (OMDS). Níveis de citocinas foram determinados nos indivíduos. RESULTADOS: 37 pacientes tinham MAH/PET. Houve correlação entre os graus de incapacidade pelas escalas. Houve também correlação entre a duração da MAH/PET e o grau da incapacidade pelas escalas. Níveis elevados de IFN-gama foram detectados em células mononucleares de sangue periférico (CMSP) não estimuladas de pacientes com MAH/PET quando comparados com indivíduos HTLV-I positivos assintomáticos. CONCLUSÃO: Os dados demonstram a validade das escalas neurológicas para classificar o grau de incapacidade neurológica em portadores do HTLV-I e sugerem o comportamento progressivo da MAH/PET. Este estudo também demonstra que os níveis de IFN-gama em sobrenadante de CMSP são marcadores da MAH/PET. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0004-282X 1678-4227 |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2006000200009Test; https://doaj.org/toc/0004-282XTest; https://doaj.org/toc/1678-4227Test |
| DOI: | 10.1590/S0004-282X2006000200009 |
| الوصول الحر: | https://doaj.org/article/7ab1541f22ec4f31ae7c46f428d5a33eTest |
| رقم الانضمام: | edsdoj.7ab1541f22ec4f31ae7c46f428d5a33e |
| قاعدة البيانات: | Directory of Open Access Journals |
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