دورية أكاديمية
The Incidence of Severe Hypercalcaemia-Induced Mental Status Changes in Patients Treated with Antibiotic-Loaded Calcium Sulphate Depot for Orthopaedic Infections
| العنوان: | The Incidence of Severe Hypercalcaemia-Induced Mental Status Changes in Patients Treated with Antibiotic-Loaded Calcium Sulphate Depot for Orthopaedic Infections |
|---|---|
| المؤلفون: | Faustine Vallon, Christoph Meier, Emanuel Gautier, Peter Wahl |
| المصدر: | Journal of Clinical Medicine, Vol 11, Iss 16, p 4900 (2022) |
| بيانات النشر: | MDPI AG, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine |
| مصطلحات موضوعية: | calcium sulphate, CaSO4, local antibiotics, carrier material, hypercalcaemia, Medicine |
| الوصف: | Local application of antibiotics with calcium-containing carrier materials (CCCM) might deliver large quantities of calcium, with some cases of hypercalcaemia reported. The incidence of symptomatic hypercalcaemia was estimated retrospectively in a consecutive, prospective series of patients treated between 10/2006 and 02/2019 with antibiotic-loaded CCCM for various orthopaedic infections. Risk factors were analysed. In the study period, 215 CCCM applications were performed. Two patients (0.9%) developed symptomatic hypercalcaemia. In one case, hypercalcaemia occurred 14 days after a second CCCM application during a staged septic hip revision. In the other case, hypercalcaemia became symptomatic six days after application of vancomycin-loaded CCCM in a component-retaining septic revision hip arthroplasty. In both cases, hypercalcemia was not imputable solely to the CCCM. Prolonged immobilization, renal impairment and other specific risk factors were present. Implantation of a CCCM for local application of antibiotics exposes the patient to large quantities of calcium during dissolution. This might induce symptomatic hypercalcaemia, a potentially life-threatening complication. The observed incidence of symptomatic hypercalcaemia remained rare ( |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2077-0383 |
| العلاقة: | https://www.mdpi.com/2077-0383/11/16/4900Test; https://doaj.org/toc/2077-0383Test |
| DOI: | 10.3390/jcm11164900 |
| الوصول الحر: | https://doaj.org/article/78dc69e7458b465ea1ec87fd75cc5184Test |
| رقم الانضمام: | edsdoj.78dc69e7458b465ea1ec87fd75cc5184 |
| قاعدة البيانات: | Directory of Open Access Journals |
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