دورية أكاديمية
Quantification of hand muscle volume and composition in patients with rheumatoid arthritis, psoriatic arthritis and psoriasis
| العنوان: | Quantification of hand muscle volume and composition in patients with rheumatoid arthritis, psoriatic arthritis and psoriasis |
|---|---|
| المؤلفون: | Andreas Friedberger, Camille Figueiredo, Alexandra Grimm, Isabelle d’Oliveira, Tobias Bäuerle, Jürgen Rech, Arnd Kleyer, David Simon, Michael Uder, Georg Schett, Klaus Engelke |
| المصدر: | BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-11 (2020) |
| بيانات النشر: | BMC, 2020. |
| سنة النشر: | 2020 |
| المجموعة: | LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Psoriasis, Psoriatic arthritis, Rheumatoid arthritis, Magnetic resonance imaging, Random forest based segmentation, Hand muscle, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Abstract Background Psoriasis (Pso), psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are inflammatory diseases. PsA and RA are characterized by bone and muscle loss. In RA, bone loss has been extensively characterized, but muscle loss has, to the best of our knowledge, not been quantified to date. Methods A random forest based segmentation method was used to analyze hand muscle volume in T1 weighted MRI images of 330 patients suffering from Pso, PsA or RA. In addition, fat volume was quantified using MRI Dixon sequences in a small subset (n = 32). Results Males had a higher relative muscle volume than females (14% for Pso, 11% for PsA, n.s. for RA). Between 40 and 80 years male Pso patients lost 13%, male PsA patients 16%, male RA patients 23% and female PsA patients 30% of their relative muscle volume. After adjustment for age, relative muscle volume in males RA patients was 16% and in female RA patients 9% lower than in Pso patients. In male RA patients relative muscle volume was 13% lower in than in male PsA patients. There was no difference in females. A significant negative correlation (R2 = 0.18) between relative intramuscular fat content relative hand muscle volume was observed. Conclusion These preliminary data showed that relative hand muscle volume significantly decreased with age in male and female patients with Pso, PsA and RA patients. Independent of age, relative hand muscle volume was significantly smaller in patients with RA compared to the patients with Pso and the difference was twice as large in males compared to females. Also in male but not in female RA patients relative hand muscle volume was significantly smaller than in PsA patients. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1471-2474 |
| العلاقة: | http://link.springer.com/article/10.1186/s12891-020-03194-5Test; https://doaj.org/toc/1471-2474Test |
| DOI: | 10.1186/s12891-020-03194-5 |
| الوصول الحر: | https://doaj.org/article/74c6bd47bd7f4ad6831b8486b102c941Test |
| رقم الانضمام: | edsdoj.74c6bd47bd7f4ad6831b8486b102c941 |
| قاعدة البيانات: | Directory of Open Access Journals |
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