دورية أكاديمية
Effect of pilocarpine mouthwash on salivary flow
| العنوان: | Effect of pilocarpine mouthwash on salivary flow |
|---|---|
| المؤلفون: | R. Bernardi, C. Perin, F.L. Becker, G.Z. Ramos, G.Z. Gheno, L.R. Lopes, M. Pires, H.M.T. Barros |
| المصدر: | Brazilian Journal of Medical and Biological Research, Vol 35, Iss 1, Pp 105-110 (2002) |
| بيانات النشر: | Associação Brasileira de Divulgação Científica, 2002. |
| سنة النشر: | 2002 |
| المجموعة: | LCC:Medicine (General) LCC:Biology (General) |
| مصطلحات موضوعية: | Pilocarpine, Mouth rinsing, Mouthwash, Xerostomia, Salivation, Medicine (General), R5-920, Biology (General), QH301-705.5 |
| الوصف: | Pilocarpine is a cholinergic agonist that increases salivary flow and has been used to treat xerostomia. Oral intake is the most frequent route of administration. Adverse effects are dose-dependent and include sudoresis, facial blushing and increased urinary frequency. The objective of the present study was to evaluate the effects of topical pilocarpine solutions as mouthwashes on salivary flow and their adverse effects on healthy subjects. Forty volunteers received 10 ml 0.5, 1 and 2% pilocarpine solutions or 0.9% saline in a randomized, double-blind, placebo-controlled manner. Salivation was measured before and 45, 60 and 75 min after mouth rinsing for 1 min with 10 ml of saline or pilocarpine solutions. Vital signs were measured and ocular, gastrointestinal and cardiovascular symptoms, anxiety and flushing were estimated using visual analog scales. There was a dose-dependent increase in salivation. Salivation measured after 1 and 2% pilocarpine (1.4 ± 0.36 and 2.22 ± 0.42 g, respectively) was significantly (P |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 0100-879X 1414-431X |
| العلاقة: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2002000100015Test; https://doaj.org/toc/0100-879XTest; https://doaj.org/toc/1414-431XTest |
| DOI: | 10.1590/S0100-879X2002000100015 |
| الوصول الحر: | https://doaj.org/article/746425af23404f66a1857baa3617e939Test |
| رقم الانضمام: | edsdoj.746425af23404f66a1857baa3617e939 |
| قاعدة البيانات: | Directory of Open Access Journals |
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