دورية أكاديمية
The Potential for Circulating Tumor Cells in Pancreatic Cancer Management
العنوان: | The Potential for Circulating Tumor Cells in Pancreatic Cancer Management |
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المؤلفون: | Michael Pimienta, Mouad Edderkaoui, Ruoxiang Wang, Stephen Pandol |
المصدر: | Frontiers in Physiology, Vol 8 (2017) |
بيانات النشر: | Frontiers Media S.A., 2017. |
سنة النشر: | 2017 |
المجموعة: | LCC:Physiology |
مصطلحات موضوعية: | circulating tumor cells, pancreatic cancer, pancreatic adenocarcinoma, metastasis, epithelial to mesenchymal transition, mesenchymal to epithelial transitions, Physiology, QP1-981 |
الوصف: | Pancreatic cancer is one the most lethal malignancies. Only a small proportion of patients with this disease benefit from surgery. Chemotherapy provides only a transient benefit. Though much effort has gone into finding new ways for early diagnosis and treatment, average patient survival has only been improved in the order of months. Circulating tumor cells (CTCs) are shed from primary tumors, including pre-malignant phases. These cells possess information about the genomic characteristics of their tumor source in situ, and their detection and characterization holds potential in early cancer diagnosis, prognosis, and treatment. Liquid Biopsies present an alternative to tumor biopsy that are hard to sample. Below we summarize current methods of CTC detection, the current literature on CTCs in pancreatic cancer, and future perspectives. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 1664-042X |
العلاقة: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00381/fullTest; https://doaj.org/toc/1664-042XTest |
DOI: | 10.3389/fphys.2017.00381 |
الوصول الحر: | https://doaj.org/article/65142cebde28457a86d9969026c465a0Test |
رقم الانضمام: | edsdoj.65142cebde28457a86d9969026c465a0 |
قاعدة البيانات: | Directory of Open Access Journals |
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