دورية أكاديمية
Efficacy and safety of anti-interleukin-1 therapeutics in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials
| العنوان: | Efficacy and safety of anti-interleukin-1 therapeutics in the treatment of knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials |
|---|---|
| المؤلفون: | Lizhi Yu, Raoshan Luo, Gang Qin, Qinyan Zhang, Weiming Liang |
| المصدر: | Journal of Orthopaedic Surgery and Research, Vol 18, Iss 1, Pp 1-16 (2023) |
| بيانات النشر: | BMC, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Orthopedic surgery LCC:Diseases of the musculoskeletal system |
| مصطلحات موضوعية: | Anti-interleukin-1 therapeutics, Meta-analysis, IL-1 antibodies, Interleukin-1 receptor antagonist, IL-1 inhibitors, Orthopedic surgery, RD701-811, Diseases of the musculoskeletal system, RC925-935 |
| الوصف: | Abstract Objective We aimed to evaluate the efficacy and safety of anti-interleukin-1 therapeutics, including IL-1 antibodies, interleukin-1 receptor antagonists (IL-1 Ras) and IL-1 inhibitors, for knee osteoarthritis (KOA) treatment. Methods Databases (Medline, Embase, Web of Science and CENTRAL) and ClinicalTrials.gov were systematically searched for randomized controlled trials (RCTs) of anti-interleukin-1 therapeutics from inception to August 31, 2022. The outcomes were the mean change in pain and function scores and the risk of adverse effects (AEs). Results In the 12 studies included, anti-interleukin-1 therapeutics were superior to placebo in terms of pain relief (standardized mean difference [SMD] = − 0.38, 95% confidence interval [CI] = − 1.82 to − 0.40, p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1749-799X |
| العلاقة: | https://doaj.org/toc/1749-799XTest |
| DOI: | 10.1186/s13018-023-03590-2 |
| الوصول الحر: | https://doaj.org/article/4fe2cf67cc8640d1a844a53508679fb4Test |
| رقم الانضمام: | edsdoj.4fe2cf67cc8640d1a844a53508679fb4 |
| قاعدة البيانات: | Directory of Open Access Journals |
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