دورية أكاديمية
Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake
| العنوان: | Assessing the Safety of Mechanically Fibrillated Cellulose Nanofibers (fib-CNF) via Toxicity Tests on Mice: Single Intratracheal Administration and 28 Days’ Oral Intake |
|---|---|
| المؤلفون: | Yoshihiro Yamashita, Akinori Tokunaga, Koji Aoki, Tamotsu Ishizuka, Hideyuki Uematsu, Hiroaki Sakamoto, Satoshi Fujita, Shuichi Tanoue |
| المصدر: | Toxics, Vol 12, Iss 2, p 121 (2024) |
| بيانات النشر: | MDPI AG, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Chemical technology |
| مصطلحات موضوعية: | cellulose, nanofiber, in vivo, TG412, TG407, safety, Chemical technology, TP1-1185 |
| الوصف: | Mechanically fibrillated cellulose nanofibers, known as fib-CNF (fiber length: 500 nm; diameter: 45 nm), are used in composites and as a natural thickener in foods. To evaluate their safety, we conducted a 28-day study in mice with inhalation exposure at 0.2 mg/body and oral administration of 400 mg/kg/day. Inhalation exposure to fib-CNF caused transient weight loss, changes in blood cell counts, and increased lung weights. These changes were attributed to adaptive responses. The oral administration of fib-CNF for 28 days resulted in no apparent toxic effects except for a slight decrease in platelet counts. The fib-CNF administration using the protocols studied appears to be safe in mice. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2305-6304 |
| العلاقة: | https://www.mdpi.com/2305-6304/12/2/121Test; https://doaj.org/toc/2305-6304Test |
| DOI: | 10.3390/toxics12020121 |
| الوصول الحر: | https://doaj.org/article/d4d5244fa412443aa425472ae08d3d8aTest |
| رقم الانضمام: | edsdoj.4d5244fa412443aa425472ae08d3d8a |
| قاعدة البيانات: | Directory of Open Access Journals |
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