دورية أكاديمية
The serum immunoglobulin G glycosylation signature of gastric cancer
العنوان: | The serum immunoglobulin G glycosylation signature of gastric cancer |
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المؤلفون: | L. Renee Ruhaak, Donald A. Barkauskas, Javier Torres, Cara L. Cooke, Lauren D. Wu, Carol Stroble, Sureyya Ozcan, Cynthia C. Williams, Margarita Camorlinga, David M. Rocke, Carlito B. Lebrilla, Jay V. Solnick |
المصدر: | EuPA Open Proteomics, Vol 6, Iss C, Pp 1-9 (2015) |
بيانات النشر: | Elsevier, 2015. |
سنة النشر: | 2015 |
المجموعة: | LCC:Genetics |
مصطلحات موضوعية: | Gastric cancer, Serum, N-glycan, Gastritis, Duodenal ulcer, Nano-LC–MS, Genetics, QH426-470 |
الوصف: | Biomarkers may facilitate detection of gastric cancer at an earlier stage and reduce mortality. Here we sought to determine if the glycosylation profile of serum immunoglobulin G (IgG) could distinguish patients with non-atrophic gastritis (NAG), duodenal ulcer (DU) and gastric cancer (GC). Serum IgG was released and analyzed using nano-LC–TOF mass spectrometry. Statistically significant false discovery rate (FDR)-adjusted p-values were observed for 18 glycans, eight that differed significantly between NAG and GC, three that distinguished NAG from DU, and eight that differed between DU and GC. The IgG glycosylation signature may be useful as a predictive marker for gastric cancer. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2212-9685 |
العلاقة: | http://www.sciencedirect.com/science/article/pii/S2212968514000683Test; https://doaj.org/toc/2212-9685Test |
DOI: | 10.1016/j.euprot.2014.11.002 |
الوصول الحر: | https://doaj.org/article/4a719a0bc21746b3b5f6ffe655bc18c3Test |
رقم الانضمام: | edsdoj.4a719a0bc21746b3b5f6ffe655bc18c3 |
قاعدة البيانات: | Directory of Open Access Journals |
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