دورية أكاديمية
Type of vaccine and immunosuppressive therapy but not diagnosis critically influence antibody response after COVID-19 vaccination in patients with rheumatic disease
العنوان: | Type of vaccine and immunosuppressive therapy but not diagnosis critically influence antibody response after COVID-19 vaccination in patients with rheumatic disease |
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المؤلفون: | Tatjana Schwarz, Gerd-Rüdiger Burmester, Florian Kurth, Jan Zernicke, Jens Klotsche, Tanja Braun, Amanthi Nadira Arumahandi de Silva, Leonie Maria Frommert, Veronika Scholz, Lara Maria Jeworowski, Victor Max Corman, Pinkus Tober-Lau, Leif Erik Sander |
المصدر: | RMD Open, Vol 8, Iss 2 (2022) |
بيانات النشر: | BMJ Publishing Group, 2022. |
سنة النشر: | 2022 |
المجموعة: | LCC:Medicine |
مصطلحات موضوعية: | Medicine |
الوصف: | Objective The development of sufficient COVID-19 vaccines has been a big breakthrough in fighting the global SARS-CoV-2 pandemic. However, vaccination effectiveness can be reduced in patients with autoimmune rheumatic diseases (AIRD). The aim of this study was to identify factors that lead to a diminished humoral vaccination response in patients with AIRD.Methods Vaccination response was measured with a surrogate virus neutralisation test and by testing for antibodies directed against the receptor-binding-domain (RBD) of SARS-CoV-2 in 308 fully vaccinated patients with AIRD. In addition, 296 immunocompetent participants were investigated as a control group. Statistical adjusted analysis included covariates with a possible influence on antibody response.Results Patients with AIRD showed lower antibody responses compared with immunocompetent individuals (median neutralising capacity 90.8% vs 96.5%, p |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | English |
تدمد: | 2056-5933 |
العلاقة: | https://rmdopen.bmj.com/content/8/2/e002650.fullTest; https://doaj.org/toc/2056-5933Test |
DOI: | 10.1136/rmdopen-2022-002650 |
الوصول الحر: | https://doaj.org/article/d451d62071de47d792f57340df2d8499Test |
رقم الانضمام: | edsdoj.451d62071de47d792f57340df2d8499 |
قاعدة البيانات: | Directory of Open Access Journals |