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Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases

التفاصيل البيبلوغرافية
العنوان: Risk of infections in bronchiectasis during disease-modifying treatment and biologics for rheumatic diseases
المؤلفون: Geri Guillaume, Dadoun Sabrina, Bui Tach, Del Castillo Pinol Nuria, Paternotte Simon, Dougados Maxime, Gossec Laure
المصدر: BMC Infectious Diseases, Vol 11, Iss 1, p 304 (2011)
بيانات النشر: BMC, 2011.
سنة النشر: 2011
المجموعة: LCC:Infectious and parasitic diseases
مصطلحات موضوعية: Infectious and parasitic diseases, RC109-216
الوصف: Abstract Background Bronchiectasis is frequently associated (up to 30%) with chronic inflammatory rheumatic diseases and leads to lower respiratory tract infections. Data are lacking on the risk of lower respiratory tract infections in patients treated with biologic agents. Methods Monocenter, retrospective systematic study of all patients with a chronic inflammatory rheumatic disease and concomitant bronchiectasis, seen between 2000 and 2009. Univariate and multivariate analyses were performed to evidence predictive factors of the number of infectious respiratory events. Results 47 patients were included (mean age 64.1 ± 9.1 years, 33 (70.2%) women), with a mean follow-up per patient of 4.3 ± 3.1 years. Rheumatoid arthritis was the main rheumatic disease (90.1%). The mean number of infectious events was 0.8 ± 1.0 event per patient-year. The factors predicting infections were the type of treatment (biologic vs. non biologic disease-modifying treatments), with an odds ratio of 8.7 (95% confidence interval: 1.7-43.4) and sputum colonization by any bacteria (odds ratio 7.4, 2.0-26.8). In multivariate analysis, both factors were independently predictive of infections. Conclusion Lower respiratory tract infectious events are frequent among patients receiving biologics for chronic inflammatory rheumatic disease associated with bronchiectasis. Biologic treatment and pre-existing sputum colonization are independent risk factors of infection occurrence.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1471-2334
العلاقة: http://www.biomedcentral.com/1471-2334/11/304Test; https://doaj.org/toc/1471-2334Test
DOI: 10.1186/1471-2334-11-304
الوصول الحر: https://doaj.org/article/383a8bdc6176494ebe366afbd497ab8cTest
رقم الانضمام: edsdoj.383a8bdc6176494ebe366afbd497ab8c
قاعدة البيانات: Directory of Open Access Journals
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