دورية أكاديمية
أعرض في EDS

Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome

التفاصيل البيبلوغرافية
العنوان: Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome
المؤلفون: Breton M. Asken, Jeremy A. Tanner, Leslie S. Gaynor, Lawren VandeVrede, William G. Mantyh, Kaitlin B. Casaletto, Adam M. Staffaroni, Corrina Fonseca, Ranjani Shankar, Harli Grant, Karen Smith, Argentina Lario Lago, Haiyan Xu, Renaud La Joie, Yann Cobigo, Howie Rosen, David C. Perry, Julio C. Rojas, Bruce L. Miller, Raquel C. Gardner, Kevin K. W. Wang, Joel H. Kramer, Gil D. Rabinovici
المصدر: Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023)
بيانات النشر: BMC, 2023.
سنة النشر: 2023
المجموعة: LCC:Neurosciences. Biological psychiatry. Neuropsychiatry
LCC:Neurology. Diseases of the nervous system
مصطلحات موضوعية: Traumatic encephalopathy syndrome, Chronic traumatic encephalopathy, Amyloid, PET, Plasma, Biomarker, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
الوصف: Abstract Background Traumatic encephalopathy syndrome (TES) is a clinical phenotype sensitive but non-specific to underlying chronic traumatic encephalopathy (CTE) neuropathology. However, cognitive symptoms of TES overlap with Alzheimer’s disease (AD), and features of AD pathology like beta-amyloid (Aβ) plaques often co-occur with CTE, making clinical-to-pathological conclusions of TES diagnoses challenging. We investigated how Alzheimer’s neuropathological changes associated with cognition, brain volume, and plasma biomarkers in patients with repetitive head impacts (RHI)/TES, clinical AD, or typically aging controls. Methods We studied 154 participants including 33 with RHI/TES (age 61.5 ± 11.5, 100% male, 11/33 Aβ[ +]), 62 with AD and no known prior RHI (age 67.1 ± 10.2, 48% male, 62/62 Aβ[ +]), and 59 healthy controls without RHI (HC; age 73.0 ± 6.2, 40% male, 0/59 Aβ[ +]). Patients completed neuropsychological testing (memory, executive functioning, language, visuospatial) and structural MRI (voxel-based morphometry analysis), and provided plasma samples analyzed for GFAP, NfL, IL-6, IFN-γ, and YKL-40. For cognition and plasma biomarkers, patients with RHI/TES were stratified as Aβ[ +] or Aβ[ −] and compared to each other plus the AD and HC groups (ANCOVA adjusting for age and sex). Differences with at least a medium effect size (Cohen’s d > 0.50) were interpreted as potentially meaningful. Results Cognitively, within the TES group, Aβ[ +] RHI/TES performed worse than Aβ[-] RHI/TES on visuospatial (p = .04, d = 0.86) and memory testing (p = .07, d = 0.74). Comparing voxel-wise brain volume, both Aβ[ +] and Aβ[ −] RHI/TES had lower medial and anterior temporal lobe volume than HC and did not significantly differ from AD. Comparing plasma biomarkers, Aβ[ +] RHI/TES had higher plasma GFAP than HC (p = .01, d = 0.88) and did not significantly differ from AD. Conversely, Aβ[ −] RHI/TES had higher NfL than HC (p = .004, d = 0.93) and higher IL-6 than all other groups (p’s ≤ .004, d’s > 1.0). Conclusions Presence of Alzheimer’s pathology in patients with RHI/TES is associated with altered cognitive and biomarker profiles. Patients with RHI/TES and positive Aβ-PET have cognitive and plasma biomarker changes that are more like patients with AD than patients with Aβ[ −] RHI/TES. Measuring well-validated Alzheimer’s biomarkers in patients with RHI/TES could improve interpretation of research findings and heighten precision in clinical management.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 1758-9193
العلاقة: https://doaj.org/toc/1758-9193Test
DOI: 10.1186/s13195-023-01275-w
الوصول الحر: https://doaj.org/article/339b6a4d0f624fd8b1dc8af195d378b2Test
رقم الانضمام: edsdoj.339b6a4d0f624fd8b1dc8af195d378b2
قاعدة البيانات: Directory of Open Access Journals
ResultId 1
Header edsdoj
Directory of Open Access Journals
edsdoj.339b6a4d0f624fd8b1dc8af195d378b2
1019
3
Academic Journal
academicJournal
1019.12707519531
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsdoj&AN=edsdoj.339b6a4d0f624fd8b1dc8af195d378b2&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doaj.org/article/339b6a4d0f624fd8b1dc8af195d378b2 [Name] => EDS - DOAJ [Category] => fullText [Text] => View record in DOAJ [MouseOverText] => View record in DOAJ ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsdoj&genre=article&issn=17589193&ISBN=&volume=15&issue=1&date=20230701&spage=1&pages=1-12&title=Alzheimer’s Research & Therapy&atitle=Alzheimer%E2%80%99s%20pathology%20is%20associated%20with%20altered%20cognition%2C%20brain%20volume%2C%20and%20plasma%20biomarker%20patterns%20in%20traumatic%20encephalopathy%20syndrome&id=DOI:10.1186/s13195-023-01275-w [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Breton+M%2E+Asken%22">Breton M. Asken</searchLink><br /><searchLink fieldCode="AR" term="%22Jeremy+A%2E+Tanner%22">Jeremy A. Tanner</searchLink><br /><searchLink fieldCode="AR" term="%22Leslie+S%2E+Gaynor%22">Leslie S. Gaynor</searchLink><br /><searchLink fieldCode="AR" term="%22Lawren+VandeVrede%22">Lawren VandeVrede</searchLink><br /><searchLink fieldCode="AR" term="%22William+G%2E+Mantyh%22">William G. Mantyh</searchLink><br /><searchLink fieldCode="AR" term="%22Kaitlin+B%2E+Casaletto%22">Kaitlin B. Casaletto</searchLink><br /><searchLink fieldCode="AR" term="%22Adam+M%2E+Staffaroni%22">Adam M. Staffaroni</searchLink><br /><searchLink fieldCode="AR" term="%22Corrina+Fonseca%22">Corrina Fonseca</searchLink><br /><searchLink fieldCode="AR" term="%22Ranjani+Shankar%22">Ranjani Shankar</searchLink><br /><searchLink fieldCode="AR" term="%22Harli+Grant%22">Harli Grant</searchLink><br /><searchLink fieldCode="AR" term="%22Karen+Smith%22">Karen Smith</searchLink><br /><searchLink fieldCode="AR" term="%22Argentina+Lario+Lago%22">Argentina Lario Lago</searchLink><br /><searchLink fieldCode="AR" term="%22Haiyan+Xu%22">Haiyan Xu</searchLink><br /><searchLink fieldCode="AR" term="%22Renaud+La+Joie%22">Renaud La Joie</searchLink><br /><searchLink fieldCode="AR" term="%22Yann+Cobigo%22">Yann Cobigo</searchLink><br /><searchLink fieldCode="AR" term="%22Howie+Rosen%22">Howie Rosen</searchLink><br /><searchLink fieldCode="AR" term="%22David+C%2E+Perry%22">David C. Perry</searchLink><br /><searchLink fieldCode="AR" term="%22Julio+C%2E+Rojas%22">Julio C. Rojas</searchLink><br /><searchLink fieldCode="AR" term="%22Bruce+L%2E+Miller%22">Bruce L. Miller</searchLink><br /><searchLink fieldCode="AR" term="%22Raquel+C%2E+Gardner%22">Raquel C. Gardner</searchLink><br /><searchLink fieldCode="AR" term="%22Kevin+K%2E+W%2E+Wang%22">Kevin K. W. Wang</searchLink><br /><searchLink fieldCode="AR" term="%22Joel+H%2E+Kramer%22">Joel H. Kramer</searchLink><br /><searchLink fieldCode="AR" term="%22Gil+D%2E+Rabinovici%22">Gil D. Rabinovici</searchLink> )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Alzheimer’s Research & Therapy, Vol 15, Iss 1, Pp 1-12 (2023) )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => BMC, 2023. )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2023 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => LCC:Neurosciences. Biological psychiatry. Neuropsychiatry<br />LCC:Neurology. Diseases of the nervous system )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Traumatic+encephalopathy+syndrome%22">Traumatic encephalopathy syndrome</searchLink><br /><searchLink fieldCode="DE" term="%22Chronic+traumatic+encephalopathy%22">Chronic traumatic encephalopathy</searchLink><br /><searchLink fieldCode="DE" term="%22Amyloid%22">Amyloid</searchLink><br /><searchLink fieldCode="DE" term="%22PET%22">PET</searchLink><br /><searchLink fieldCode="DE" term="%22Plasma%22">Plasma</searchLink><br /><searchLink fieldCode="DE" term="%22Biomarker%22">Biomarker</searchLink><br /><searchLink fieldCode="DE" term="%22Neurosciences%2E+Biological+psychiatry%2E+Neuropsychiatry%22">Neurosciences. Biological psychiatry. Neuropsychiatry</searchLink><br /><searchLink fieldCode="DE" term="%22RC321-571%22">RC321-571</searchLink><br /><searchLink fieldCode="DE" term="%22Neurology%2E+Diseases+of+the+nervous+system%22">Neurology. Diseases of the nervous system</searchLink><br /><searchLink fieldCode="DE" term="%22RC346-429%22">RC346-429</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Abstract Background Traumatic encephalopathy syndrome (TES) is a clinical phenotype sensitive but non-specific to underlying chronic traumatic encephalopathy (CTE) neuropathology. However, cognitive symptoms of TES overlap with Alzheimer’s disease (AD), and features of AD pathology like beta-amyloid (Aβ) plaques often co-occur with CTE, making clinical-to-pathological conclusions of TES diagnoses challenging. We investigated how Alzheimer’s neuropathological changes associated with cognition, brain volume, and plasma biomarkers in patients with repetitive head impacts (RHI)/TES, clinical AD, or typically aging controls. Methods We studied 154 participants including 33 with RHI/TES (age 61.5 ± 11.5, 100% male, 11/33 Aβ[ +]), 62 with AD and no known prior RHI (age 67.1 ± 10.2, 48% male, 62/62 Aβ[ +]), and 59 healthy controls without RHI (HC; age 73.0 ± 6.2, 40% male, 0/59 Aβ[ +]). Patients completed neuropsychological testing (memory, executive functioning, language, visuospatial) and structural MRI (voxel-based morphometry analysis), and provided plasma samples analyzed for GFAP, NfL, IL-6, IFN-γ, and YKL-40. For cognition and plasma biomarkers, patients with RHI/TES were stratified as Aβ[ +] or Aβ[ −] and compared to each other plus the AD and HC groups (ANCOVA adjusting for age and sex). Differences with at least a medium effect size (Cohen’s d > 0.50) were interpreted as potentially meaningful. Results Cognitively, within the TES group, Aβ[ +] RHI/TES performed worse than Aβ[-] RHI/TES on visuospatial (p = .04, d = 0.86) and memory testing (p = .07, d = 0.74). Comparing voxel-wise brain volume, both Aβ[ +] and Aβ[ −] RHI/TES had lower medial and anterior temporal lobe volume than HC and did not significantly differ from AD. Comparing plasma biomarkers, Aβ[ +] RHI/TES had higher plasma GFAP than HC (p = .01, d = 0.88) and did not significantly differ from AD. Conversely, Aβ[ −] RHI/TES had higher NfL than HC (p = .004, d = 0.93) and higher IL-6 than all other groups (p’s ≤ .004, d’s > 1.0). Conclusions Presence of Alzheimer’s pathology in patients with RHI/TES is associated with altered cognitive and biomarker profiles. Patients with RHI/TES and positive Aβ-PET have cognitive and plasma biomarker changes that are more like patients with AD than patients with Aβ[ −] RHI/TES. Measuring well-validated Alzheimer’s biomarkers in patients with RHI/TES could improve interpretation of research findings and heighten precision in clinical management. )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article )
Array ( [Name] => Format [Label] => File Description [Group] => SrcInfo [Data] => electronic resource )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1758-9193 )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://doaj.org/toc/1758-9193 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1186/s13195-023-01275-w )
Array ( [Name] => URL [Label] => Access URL [Group] => URL [Data] => <link linkTarget="URL" linkTerm="https://doaj.org/article/339b6a4d0f624fd8b1dc8af195d378b2" linkWindow="_blank">https://doaj.org/article/339b6a4d0f624fd8b1dc8af195d378b2</link> )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsdoj.339b6a4d0f624fd8b1dc8af195d378b2 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1186/s13195-023-01275-w ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [PhysicalDescription] => Array ( [Pagination] => Array ( [PageCount] => 12 [StartPage] => 1 ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Traumatic encephalopathy syndrome [Type] => general ) [1] => Array ( [SubjectFull] => Chronic traumatic encephalopathy [Type] => general ) [2] => Array ( [SubjectFull] => Amyloid [Type] => general ) [3] => Array ( [SubjectFull] => PET [Type] => general ) [4] => Array ( [SubjectFull] => Plasma [Type] => general ) [5] => Array ( [SubjectFull] => Biomarker [Type] => general ) [6] => Array ( [SubjectFull] => Neurosciences. Biological psychiatry. Neuropsychiatry [Type] => general ) [7] => Array ( [SubjectFull] => RC321-571 [Type] => general ) [8] => Array ( [SubjectFull] => Neurology. Diseases of the nervous system [Type] => general ) [9] => Array ( [SubjectFull] => RC346-429 [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Alzheimer’s pathology is associated with altered cognition, brain volume, and plasma biomarker patterns in traumatic encephalopathy syndrome [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Breton M. Asken ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jeremy A. Tanner ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Leslie S. Gaynor ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lawren VandeVrede ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => William G. Mantyh ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kaitlin B. Casaletto ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Adam M. Staffaroni ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Corrina Fonseca ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ranjani Shankar ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Harli Grant ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Karen Smith ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Argentina Lario Lago ) ) ) [12] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Haiyan Xu ) ) ) [13] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Renaud La Joie ) ) ) [14] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Yann Cobigo ) ) ) [15] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Howie Rosen ) ) ) [16] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => David C. Perry ) ) ) [17] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Julio C. Rojas ) ) ) [18] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bruce L. Miller ) ) ) [19] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Raquel C. Gardner ) ) ) [20] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kevin K. W. Wang ) ) ) [21] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Joel H. Kramer ) ) ) [22] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gil D. Rabinovici ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 07 [Type] => published [Y] => 2023 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 17589193 ) ) [Numbering] => Array ( [0] => Array ( [Type] => volume [Value] => 15 ) [1] => Array ( [Type] => issue [Value] => 1 ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Alzheimer’s Research & Therapy [Type] => main ) ) ) ) ) ) )
IllustrationInfo