دورية أكاديمية
Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation
| العنوان: | Effector and Regulatory T Cells Roll at High Shear Stress by Inducible Tether and Sling Formation |
|---|---|
| المؤلفون: | Michael Abadier, Akula Bala Pramod, Sara McArdle, Alex Marki, Zhichao Fan, Edgar Gutierrez, Alex Groisman, Klaus Ley |
| المصدر: | Cell Reports, Vol 21, Iss 13, Pp 3885-3899 (2017) |
| بيانات النشر: | Elsevier, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Biology (General) |
| مصطلحات موضوعية: | CD4 T cell subsets, rolling, P-selectin, E-selectin, PSGL-1, tethers, slings, RNA-seq, Biology (General), QH301-705.5 |
| الوصف: | The adaptive immune response involves T cell differentiation and migration to sites of inflammation. T cell trafficking is initiated by rolling on inflamed endothelium. Tethers and slings, discovered in neutrophils, facilitate cell rolling at high shear stress. Here, we demonstrate that the ability to form tethers and slings during rolling is highly inducible in T helper 1 (Th1), Th17, and regulatory T (Treg) cells but less in Th2 cells. In vivo, endogenous Treg cells rolled stably in cremaster venules at physiological shear stress. Quantitative dynamic footprinting nanoscopy of Th1, Th17, and Treg cells uncovered the formation of multiple tethers per cell. Human Th1 cells also showed tethers and slings. RNA sequencing (RNA-seq) revealed the induction of cell migration and cytoskeletal genes in sling-forming cells. We conclude that differentiated CD4 T cells stabilize rolling by inducible tether and sling formation. These phenotypic changes approximate the adhesion phenotype of neutrophils and support CD4 T cell access to sites of inflammation. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2211-1247 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2211124717317837Test; https://doaj.org/toc/2211-1247Test |
| DOI: | 10.1016/j.celrep.2017.11.099 |
| الوصول الحر: | https://doaj.org/article/2cf9a5879a9f4aa698706144be6e373fTest |
| رقم الانضمام: | edsdoj.2cf9a5879a9f4aa698706144be6e373f |
| قاعدة البيانات: | Directory of Open Access Journals |
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