دورية أكاديمية

Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis

التفاصيل البيبلوغرافية
العنوان: Adipose Tissue and Adipose-Tissue-Derived Cell Therapies for the Treatment of the Face and Hands of Patients Suffering from Systemic Sclerosis
المؤلفون: Anouck Coulange Zavarro, Mélanie Velier, Robin Arcani, Maxime Abellan Lopez, Stéphanie Simoncini, Audrey Benyamine, Quentin Gomes De Pinho, Raphael Coatmeur, Jiucun Wang, Jingjing Xia, Ludovica Barone, Dominique Casanova, Françoise Dignat-George, Florence Sabatier, Brigitte Granel, Jérémy Magalon, Aurélie Daumas
المصدر: Biomedicines, Vol 11, Iss 2, p 348 (2023)
بيانات النشر: MDPI AG, 2023.
سنة النشر: 2023
المجموعة: LCC:Biology (General)
مصطلحات موضوعية: systemic sclerosis, adipose tissue, adipose-tissue-derived cell therapy, fat grafting, stromal vascular fraction, adipose-derived stromal/stem cell, Biology (General), QH301-705.5
الوصف: Adipose tissue is recognized as a valuable source of cells with angiogenic, immunomodulatory, reparative and antifibrotic properties and emerged as a therapeutic alternative for the regeneration and repair of damaged tissues. The use of adipose-tissue-based therapy is expanding in autoimmune diseases, particularly in Systemic Sclerosis (SSc), a disease in which hands and face are severely affected, leading to disability and a decrease in quality of life. Combining the advantage of an abundant supply of fat tissue and a high abundance of stem/stromal cells, fat grafting and adipose tissue-derived cell-based therapies are attractive therapeutic options in SSc. This review aims to synthesize the evidence to determine the effects of the use of these biological products for face and hands treatment in the context of SSc. This highlights several points: the need to use relevant effectiveness criteria taking into account the clinical heterogeneity of SSc in order to facilitate assessment and comparison of innovative therapies; second, it reveals some impacts of the disease on fat-grafting success; third, an important heterogeneity was noticed regarding the manufacturing of the adipose-derived products and lastly, it shows a lack of robust evidence from controlled trials comparing adipose-derived products with standard care.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2227-9059
العلاقة: https://www.mdpi.com/2227-9059/11/2/348Test; https://doaj.org/toc/2227-9059Test
DOI: 10.3390/biomedicines11020348
الوصول الحر: https://doaj.org/article/a236661e4c394a7ab6396b0ef07745e4Test
رقم الانضمام: edsdoj.236661e4c394a7ab6396b0ef07745e4
قاعدة البيانات: Directory of Open Access Journals
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