دورية أكاديمية
Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding
| العنوان: | Cryo-EM demonstrates the in vitro proliferation of an ex vivo amyloid fibril morphology by seeding |
|---|---|
| المؤلفون: | Thomas Heerde, Matthies Rennegarbe, Alexander Biedermann, Dilan Savran, Peter B. Pfeiffer, Manuel Hitzenberger, Julian Baur, Ioana Puscalau-Girtu, Martin Zacharias, Nadine Schwierz, Christian Haupt, Matthias Schmidt, Marcus Fändrich |
| المصدر: | Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Here, the authors present the cryo-EM structure of in vitro amyloid fibrils from recombinant SAA1.1 protein that were formed by seeding with fibrils purified from systemic AA amyloidosis tissue. This in vitro fibril structure resembles the structure of the ex vivo fibrils but differs from unseeded in vitro fibrils. These findings show that fibril morphologies can be propagated in vitro by seeding. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://doaj.org/toc/2041-1723Test |
| DOI: | 10.1038/s41467-021-27688-5 |
| الوصول الحر: | https://doaj.org/article/1dc8229b0dcb4b2fa12efbe783d6a181Test |
| رقم الانضمام: | edsdoj.1dc8229b0dcb4b2fa12efbe783d6a181 |
| قاعدة البيانات: | Directory of Open Access Journals |
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