دورية أكاديمية
Clinical Efficiency and Safety of Hypofractionated Thoracic Radiotherapy Combined with EP Chemotherapy on Patients with Limited-stage Small-cell Lung Cancer
العنوان: | Clinical Efficiency and Safety of Hypofractionated Thoracic Radiotherapy Combined with EP Chemotherapy on Patients with Limited-stage Small-cell Lung Cancer |
---|---|
المؤلفون: | HE Yisheng, BAO Liangliang, YU Jiawen, Lyu Yang |
المصدر: | Zhongliu Fangzhi Yanjiu, Vol 50, Iss 2, Pp 170-174 (2023) |
بيانات النشر: | Magazine House of Cancer Research on Prevention and Treatment, 2023. |
سنة النشر: | 2023 |
المجموعة: | LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
مصطلحات موضوعية: | hypofractionated radiotherapy, ep chemotherapy, limited-stage small-cell lung cancer, clinical efficiency, safety, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
الوصف: | Objective To investigate the efficacy and safety of hypofractionated thoracic radiotherapy combined with EP chemotherapy in the treatment of limited-stage small-cell lung cancer (LS-SCLC). Methods A total of 117 patients with LS-SCLC were enrolled and randomly divided into test group (n=59) and control group (n=58). Patients in the experiment group were given hypofractionated thoracic radiotherapy combined with EP chemotherapy, while patients in the control group were given hyperfractionation radiotherapy combined with EP chemotherapy. Objective response rate (ORR), 2-year overall survival (OS), 2-year progression free survival (PFS), and immune cell level were used to evaluate clinical efficacy. We compared the incidence of side effects between the two groups. Results After the treatment, the ORR of patients in the test group was higher than that in the control group (P > 0.05). The mean OS and PFS of patients in the test group were significantly longer than those in the control group (P < 0.05). The levels of CD3+, CD4+, CD4+/CD8+, and NK cells in the test group were significantly higher, whereas the levels of CD8+ were significantly lower than those in the control group (P < 0.05). The incidence of radiation pneumonitis, radiation esophagitis, and severe dermatitis in the test group was significantly lower than that in the control group (P < 0.05). Conclusion Hypofractionated radiotherapy combined with EP chemotherapy for treatment of LS-SCLC can effectively improve the anticancer efficacy and patient survival, reduce the damage to the body's immune function, and alleviate adverse reaction of radiotherapy. |
نوع الوثيقة: | article |
وصف الملف: | electronic resource |
اللغة: | Chinese |
تدمد: | 1000-8578 |
العلاقة: | http://www.zlfzyj.com/EN/10.3971/j.issn.1000-8578.2023.22.0848Test; https://doaj.org/toc/1000-8578Test |
DOI: | 10.3971/j.issn.1000-8578.2023.22.0848 |
الوصول الحر: | https://doaj.org/article/0a5906d12f304b2e864397e182a3a46eTest |
رقم الانضمام: | edsdoj.0a5906d12f304b2e864397e182a3a46e |
قاعدة البيانات: | Directory of Open Access Journals |