دورية أكاديمية
The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population
| العنوان: | The Variant rs1784042 of the SIDT2 Gene is Associated with Metabolic Syndrome through Low HDL-c Levels in a Mexican Population |
|---|---|
| المؤلفون: | Guadalupe León-Reyes, Berenice Rivera-Paredez, Juan Carlos Fernandez López, Eric G. Ramírez-Salazar, Arnoldo Aquino-Gálvez, Katia Gallegos-Carrillo, Edgar Denova-Gutiérrez, Jorge Salmerón, Rafael Velázquez-Cruz |
| المصدر: | Genes, Vol 11, Iss 1192, p 1192 (2020) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | SIDT2 gene, HDL-c, metabolic syndrome, rs17120425, rs1784042, type 2 diabetes, Genetics, QH426-470 |
| الوصف: | The Mexican population has one of the highest prevalences of metabolic syndrome (MetS) worldwide. The aim of this study was to investigate the association of single-nucleotide polymorphisms (SNPs) with MetS and its components. First, we performed a pilot Genome-wide association study (GWAS) scan on a sub-sample derived from the Health Workers Cohort Study (HWCS) ( n = 411). Based on GWAS results, we selected the rs1784042 and rs17120425 SNPs in the SIDT1 transmembrane family member 2 ( SIDT2 ) gene for replication in the entire cohort ( n = 1963), using predesigned TaqMan assays. We observed a prevalence of MetS in the HWCS of 52.6%. The minor allele frequency for the variant rs17120425 was 10% and 29% for the rs1784042. The SNP rs1784042 showed an overall association with MetS (OR = 0.82, p = 0.01) and with low levels of high-density lipoprotein (HDL-c) (odds ratio (OR) = 0.77, p = 0.001). The SNP rs17120425 had a significant association with type 2 diabetes (T2D) risk in the overall population (OR = 1.39, p = 0.033). Our results suggest an association of the rs1784042 and rs17120425 variants with MetS, through different mechanisms in the Mexican population. Further studies in larger samples and other populations are required to validate these findings and the relevance of these SNPs in MetS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2073-4425 |
| العلاقة: | https://www.mdpi.com/2073-4425/11/10/1192Test; https://doaj.org/toc/2073-4425Test; https://doaj.org/article/4bc225fdd3c74b83b21d417964fe461aTest |
| DOI: | 10.3390/genes11101192 |
| الإتاحة: | https://doi.org/10.3390/genes11101192Test https://doaj.org/article/4bc225fdd3c74b83b21d417964fe461aTest |
| رقم الانضمام: | edsbas.F8643768 |
| قاعدة البيانات: | BASE |
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