دورية أكاديمية
Efficient synthesis and characterization of imidazo[1,2‐a]pyridine‐8‐carboxamide derivatives: A promising scaffold for drug development
| العنوان: | Efficient synthesis and characterization of imidazo[1,2‐a]pyridine‐8‐carboxamide derivatives: A promising scaffold for drug development |
|---|---|
| المؤلفون: | Bhatt, Keval, Patel, Dhara, Rathod, Mrudangsinh, Patel, Ashish, Shah, Drashti |
| المصدر: | Vietnam Journal of Chemistry ; ISSN 2572-8288 2572-8288 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2024 |
| المجموعة: | Wiley Online Library (Open Access Articles via Crossref) |
| الوصف: | Imidazo[1,2‐ a ]pyridine, a pivotal fused heterocycle with widespread applications in medicinal chemistry, serves as a foundational scaffold for numerous pharmaceutical compounds. This present approach introduces a highly efficient multi‐step synthetic methodology for imidazo[1,2‐ a ]pyridine‐8‐carboxamide derivatives through a condensation reaction between 2‐aminonicotinic acid and chloroacetaldehyde in an environmentally friendly ethanol solvent followed by acid‐amine coupling reaction with a substituted amine. This coupling reaction employs an HATU catalyst and DIPEA strong base and affords excellent yields (93%–97%). A total of ten derivatives have been developed and elucidated by spectral methods, including FT‐IR, 1 H NMR, and mass spectrometry. In summary, this synthetic strategy possesses favorable attributes for the synthesis of imidazo[1,2‐ a ]pyridine‐8‐carboxamide derivatives, such as good purity, readily available starting substrates, wide substrate applicability with simple scale‐up and convenient workup procedure. These characteristics render it a promising method for advanced refinement and prospective utilization in synthesizing crucial therapeutic agents. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1002/vjch.202300362 |
| الإتاحة: | https://doi.org/10.1002/vjch.202300362Test |
| حقوق: | http://onlinelibrary.wiley.com/termsAndConditions#vorTest |
| رقم الانضمام: | edsbas.F79AB521 |
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