دورية أكاديمية
Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia
| العنوان: | Increased severity of fragile X spectrum disorders in the agricultural community of Ricaurte, Colombia |
|---|---|
| المؤلفون: | Saldarriaga, Wilmar, Salcedo‐Arellano, María J, Rodriguez‐Guerrero, Tatiana, Ríos, Marcela, Fandiño‐Losada, Andrés, Ramirez‐Cheyne, Julian, Lein, Pamela J, Tassone, Flora, Hagerman, Randi J |
| المصدر: | International Journal of Developmental Neuroscience, vol 72, iss 1 |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2019 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Biomedical and Clinical Sciences, Clinical Sciences, Psychology, Brain Disorders, Intellectual and Developmental Disabilities (IDD), Mental Health, Pediatric, Rare Diseases, Clinical Trials and Supportive Activities, Fragile X Syndrome, Clinical Research, Rural Health, Autism, Behavioral and Social Science, Aetiology, 2.1 Biological and endogenous factors, Adolescent, Adult, Aged, 80 and over, Agriculture, Child, Preschool, Cognition Disorders, Colombia, Female, Fragile X Mental Retardation Protein, Humans, Infant, Male |
| جغرافية الموضوع: | 1 - 5 |
| الوصف: | Premutation carriers of the FMR1 gene (CGG repeats between 55 and 200) usually have normal intellectual abilities but approximately 20% are diagnosed with developmental problems or autism spectrum disorder. Additionally, close to 50% have psychiatric problems such as anxiety, ADHD and/or depression. The spectrum of fragile X disorders also includes Fragile-X-associated primary ovarian insufficiency (FXPOI) in female carriers and Fragile-X-associated tremor/ataxia syndrome (FXTAS) in older male and female carriers. We evaluated 25 premutation carriers in the rural community of Ricaurte Colombia and documented all behavioral problems, social deficits and clinical signs of FXPOI and FXTAS as well as reviewed the medical and obstetric history. We found an increased frequency and severity of symptoms of fragile X spectrum disorders, which might be related to the vulnerability of FMR1 premutation carriers to higher exposure to neurotoxic pesticides in this rural community. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | qt8785n0c0; https://escholarship.org/uc/item/8785n0c0Test |
| الإتاحة: | https://escholarship.org/uc/item/8785n0c0Test |
| حقوق: | public |
| رقم الانضمام: | edsbas.F696AA9 |
| قاعدة البيانات: | BASE |
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