دورية أكاديمية
The Human Protein Atlas - a tool for pathology
العنوان: | The Human Protein Atlas - a tool for pathology |
---|---|
المؤلفون: | Ponten, F., Jirström, Karin, Uhlen, M. |
المصدر: | Journal of Pathology; 216(4), pp 387-393 (2008) ; ISSN: 0022-3417 |
بيانات النشر: | John Wiley & Sons Inc. |
سنة النشر: | 2008 |
المجموعة: | Lund University Publications (LUP) |
مصطلحات موضوعية: | Cell and Molecular Biology, Cancer and Oncology, Databases, Protein, Genome, Human, Humans, Immunohistochemistry, Pathology/methods, Proteome, Proteomics |
الوصف: | Tissue-based diagnostics and research is incessantly evolving with the development of new molecular tools. It has long been realized that immunohistochemistry can add an important new level of information on top of morphology and that protein expression patterns in a cancer may yield crucial diagnostic and prognostic information. We have generated an immunohistochemistry-based map of protein expression profiles in normal tissues, cancer and cell lines. For each antibody, altogether 708 spots of tissues and cells are analysed and the resulting images and data are presented as freely available in the Human Protein Atlas (www.proteinatlas.org). The new version 4 of the atlas, including more than 5 million images of immunohistochemically stained tissues and cells, is based on 6122 antibodies, representing 5011 human proteins encoded by approximately 25% of the human genome. The gene-centric database includes a putative classification of proteins in various protein classes, both functional classes, such as kinases or transcription factors and project-related classes, such as candidate genes for cancer or cardiovascular diseases. For each of the internally generated antibodies, the exact antigen sequence is presented, together with a visualization of application-specific validation data, including a protein array assay, western blot analysis, immunohistochemistry and, in most cases, immunofluorescent-based confocal microscopy. The updated version also includes new search algorithms to allow complex queries regarding expression profiles, protein classes and chromosome location. Thus, the presented Human Protein Atlas provides a resource for pathology-based biomedical research, including protein science and biomarker discovery. |
نوع الوثيقة: | article in journal/newspaper other non-article part of journal/newspaper |
اللغة: | English |
العلاقة: | https://lup.lub.lu.se/record/1305523Test; http://dx.doi.org/10.1002/path.2440Test; wos:000261509200001; scopus:57149110826; pmid:18853439 |
DOI: | 10.1002/path.2440 |
الإتاحة: | https://doi.org/10.1002/path.2440Test https://lup.lub.lu.se/record/1305523Test |
رقم الانضمام: | edsbas.F5905405 |
قاعدة البيانات: | BASE |
ResultId |
1 |
---|---|
Header |
edsbas BASE edsbas.F5905405 724 3 Academic Journal academicJournal 723.664306640625 |
PLink |
https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.F5905405&custid=s6537998&authtype=sso |
FullText |
Array
(
[Availability] => 0
)
Array ( [0] => Array ( [Url] => https://doi.org/10.1002/path.2440# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) ) |
Items |
Array
(
[Name] => Title
[Label] => Title
[Group] => Ti
[Data] => The Human Protein Atlas - a tool for pathology
)
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Ponten%2C+F%2E%22">Ponten, F.</searchLink><br /><searchLink fieldCode="AR" term="%22Jirström%2C+Karin%22">Jirström, Karin</searchLink><br /><searchLink fieldCode="AR" term="%22Uhlen%2C+M%2E%22">Uhlen, M.</searchLink> ) Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => Journal of Pathology; 216(4), pp 387-393 (2008) ; ISSN: 0022-3417 ) Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => John Wiley & Sons Inc. ) Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2008 ) Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Lund University Publications (LUP) ) Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Cell+and+Molecular+Biology%22">Cell and Molecular Biology</searchLink><br /><searchLink fieldCode="DE" term="%22Cancer+and+Oncology%22">Cancer and Oncology</searchLink><br /><searchLink fieldCode="DE" term="%22Databases%22">Databases</searchLink><br /><searchLink fieldCode="DE" term="%22Protein%22">Protein</searchLink><br /><searchLink fieldCode="DE" term="%22Genome%22">Genome</searchLink><br /><searchLink fieldCode="DE" term="%22Human%22">Human</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Immunohistochemistry%22">Immunohistochemistry</searchLink><br /><searchLink fieldCode="DE" term="%22Pathology%2Fmethods%22">Pathology/methods</searchLink><br /><searchLink fieldCode="DE" term="%22Proteome%22">Proteome</searchLink><br /><searchLink fieldCode="DE" term="%22Proteomics%22">Proteomics</searchLink> ) Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Tissue-based diagnostics and research is incessantly evolving with the development of new molecular tools. It has long been realized that immunohistochemistry can add an important new level of information on top of morphology and that protein expression patterns in a cancer may yield crucial diagnostic and prognostic information. We have generated an immunohistochemistry-based map of protein expression profiles in normal tissues, cancer and cell lines. For each antibody, altogether 708 spots of tissues and cells are analysed and the resulting images and data are presented as freely available in the Human Protein Atlas (www.proteinatlas.org). The new version 4 of the atlas, including more than 5 million images of immunohistochemically stained tissues and cells, is based on 6122 antibodies, representing 5011 human proteins encoded by approximately 25% of the human genome. The gene-centric database includes a putative classification of proteins in various protein classes, both functional classes, such as kinases or transcription factors and project-related classes, such as candidate genes for cancer or cardiovascular diseases. For each of the internally generated antibodies, the exact antigen sequence is presented, together with a visualization of application-specific validation data, including a protein array assay, western blot analysis, immunohistochemistry and, in most cases, immunofluorescent-based confocal microscopy. The updated version also includes new search algorithms to allow complex queries regarding expression profiles, protein classes and chromosome location. Thus, the presented Human Protein Atlas provides a resource for pathology-based biomedical research, including protein science and biomarker discovery. ) Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper<br />other non-article part of journal/newspaper ) Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English ) Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => https://lup.lub.lu.se/record/1305523; http://dx.doi.org/10.1002/path.2440; wos:000261509200001; scopus:57149110826; pmid:18853439 ) Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1002/path.2440 ) Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/10.1002/path.2440<br />https://lup.lub.lu.se/record/1305523 ) Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.F5905405 ) |
RecordInfo |
Array
(
[BibEntity] => Array
(
[Identifiers] => Array
(
[0] => Array
(
[Type] => doi
[Value] => 10.1002/path.2440
)
)
[Languages] => Array
(
[0] => Array
(
[Text] => English
)
)
[Subjects] => Array
(
[0] => Array
(
[SubjectFull] => Cell and Molecular Biology
[Type] => general
)
[1] => Array
(
[SubjectFull] => Cancer and Oncology
[Type] => general
)
[2] => Array
(
[SubjectFull] => Databases
[Type] => general
)
[3] => Array
(
[SubjectFull] => Protein
[Type] => general
)
[4] => Array
(
[SubjectFull] => Genome
[Type] => general
)
[5] => Array
(
[SubjectFull] => Human
[Type] => general
)
[6] => Array
(
[SubjectFull] => Humans
[Type] => general
)
[7] => Array
(
[SubjectFull] => Immunohistochemistry
[Type] => general
)
[8] => Array
(
[SubjectFull] => Pathology/methods
[Type] => general
)
[9] => Array
(
[SubjectFull] => Proteome
[Type] => general
)
[10] => Array
(
[SubjectFull] => Proteomics
[Type] => general
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => The Human Protein Atlas - a tool for pathology
[Type] => main
)
)
)
[BibRelationships] => Array
(
[HasContributorRelationships] => Array
(
[0] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Ponten, F.
)
)
)
[1] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Jirström, Karin
)
)
)
[2] => Array
(
[PersonEntity] => Array
(
[Name] => Array
(
[NameFull] => Uhlen, M.
)
)
)
)
[IsPartOfRelationships] => Array
(
[0] => Array
(
[BibEntity] => Array
(
[Dates] => Array
(
[0] => Array
(
[D] => 01
[M] => 01
[Type] => published
[Y] => 2008
)
)
[Identifiers] => Array
(
[0] => Array
(
[Type] => issn-locals
[Value] => edsbas
)
)
[Titles] => Array
(
[0] => Array
(
[TitleFull] => Journal of Pathology; 216(4), pp 387-393 (2008) ; ISSN: 0022-3417
[Type] => main
)
)
)
)
)
)
)
|
IllustrationInfo |