دورية أكاديمية
Abstract Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins
العنوان: | Abstract Conserved motifs in voltage-sensing and pore-forming modules of voltage-gated ion channel proteins |
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المؤلفون: | Purnima Guda A, Philip E. Bourne B, Chittibabu Guda A |
المساهمون: | The Pennsylvania State University CiteSeerX Archives |
المصدر: | http://www.sdsc.edu/pb/papers/guda06.pdfTest. |
سنة النشر: | 2006 |
المجموعة: | CiteSeerX |
مصطلحات موضوعية: | Voltage-gated ion channel proteins, VGC proteins, VGC motifs, Calcium channel proteins, Potassium channel proteins, Sodium channel |
الوصف: | Voltage-gated ion channels (VGCs) mediate selective diffusion of ions across cell membranes to enable many vital cellular processes. Three-dimensional structure data are lacking for VGC proteins; hence, to better understand their function, there is a need to identify the conserved motifs using sequence analysis methods. In this study, we have used a profile-to-profile alignment method to identify several new conserved motifs specific to each transmembrane segment (TMS) of the voltage-sensing and the pore-forming modules of Ca 2+, Na +, and K + channel subfamilies. For Ca 2+ and Na +, the functional theme of motif conservation is similar in all segments while they differ with those of the K + channel proteins. Nevertheless, the conservation is strikingly similar in the S4 segment of the voltage-sensing module across all subfamilies. In each subfamily and for each TMS, we have identified conserved motifs/residues and correlated their functional significance and disease associations in human, using mutational data from the literature. |
نوع الوثيقة: | text |
وصف الملف: | application/pdf |
اللغة: | English |
العلاقة: | http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.74.2234Test; http://www.sdsc.edu/pb/papers/guda06.pdfTest |
الإتاحة: | http://www.sdsc.edu/pb/papers/guda06.pdfTest |
حقوق: | Metadata may be used without restrictions as long as the oai identifier remains attached to it. |
رقم الانضمام: | edsbas.F5742457 |
قاعدة البيانات: | BASE |
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