دورية أكاديمية
أعرض في EDS

The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease

التفاصيل البيبلوغرافية
العنوان: The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease
المؤلفون: Fu, Guangzhen, Hu, Mei, Chu, Lina, Zhang, Man
المساهمون: Zhang, M (reprint author), Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China., Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China., Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China.
المصدر: SCI ; PubMed
بيانات النشر: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
سنة النشر: 2015
المجموعة: Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
مصطلحات موضوعية: CARDIOVASCULAR-DISEASE, FIBRINOPEPTIDE-A, RISK-FACTORS, BIOMARKERS, DISCOVERY, FIBRINOGEN, PROTEOMICS, MELLITUS, CANCER, HEART
الوصف: Objectives. We aim to explore urinary biomarkers that could monitor CAD in type 2 diabetic patients. Materials and Methods. Urine samples from two groups, twenty-eight type 2 diabetic patients with coexisting CAD and thirty type 2 diabetic patients without CAD, were purified by MB-WCX and then analyzed by MALDI-TOF-MS. Subsequently, we compared the urinary peptide signatures of the two groups by use of ClinProTools2.1 and evaluated the potential ability of the differently expressed peptides to distinguish type 2 diabetic patients with coexisting CAD from type 2 diabetic patients without CAD by ROC analysis. Finally, the differently expressed peptides were identified by nanoliquid chromatography-tandem mass spectrometry. Results. There were six differently expressed peptides (m/z 1305.2, 1743.9, 2184.9, 2756.1, 3223.2, and 6196.1) between the two groups of subjects, and they were identified as fragments of isoform 1 of fibrinogen alpha chain precursor, prothrombin precursor, and interalpha-trypsin inhibitor heavy chain H4. The diagnostic efficacy of m/z 2756.1 and m/z 3223.2 was better than the other peptides. Area under ROC of the m/z 2756.1, and m/z 3223.2 was 0.98 and 0.93, respectively. Conclusions. These urinary peptides are potential urinary biomarkers for monitoring of type 2 diabetic patients with CAD. ; Capital Health Research and Development of Special [2011-2008-02]; National Key Technology R&D Program: Key technology and application research of pre-pregnacy eugenics [2013BAI12B01-4] ; SCI(E) ; PubMed ; ARTICLE ; mzhang99@aliyun.com ; 758402 ; 2015
نوع الوثيقة: journal/newspaper
اللغة: English
تدمد: 1687-8337
1687-8345
العلاقة: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.2015.; 1302773; http://hdl.handle.net/20.500.11897/419235Test; WOS:000355463600001
DOI: 10.1155/2015/758402
الإتاحة: https://doi.org/20.500.11897/419235Test
https://doi.org/10.1155/2015/758402Test
https://hdl.handle.net/20.500.11897/419235Test
رقم الانضمام: edsbas.F4DA55F3
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.F4DA55F3
792
3
Academic Journal
academicJournal
792.1474609375
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.F4DA55F3&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/20.500.11897/419235# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsbas&genre=article&issn=16878337&ISBN=&volume=&issue=&date=20150101&spage=&pages=&title=SCI ; PubMed&atitle=The%20Difference%20Quantity%20of%20Urinary%20Peptides%20between%20Two%20Groups%20of%20Type%202%20Diabetic%20Patients%20with%20or%20without%20Coronary%20Artery%20Disease&id=DOI:10.1155/2015/758402 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Fu%2C+Guangzhen%22">Fu, Guangzhen</searchLink><br /><searchLink fieldCode="AR" term="%22Hu%2C+Mei%22">Hu, Mei</searchLink><br /><searchLink fieldCode="AR" term="%22Chu%2C+Lina%22">Chu, Lina</searchLink><br /><searchLink fieldCode="AR" term="%22Zhang%2C+Man%22">Zhang, Man</searchLink> )
Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Zhang, M (reprint author), Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China.<br />Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China.<br />Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China. )
Array ( [Name] => TitleSource [Label] => Source [Group] => Src [Data] => SCI ; PubMed )
Array ( [Name] => Publisher [Label] => Publisher Information [Group] => PubInfo [Data] => INTERNATIONAL JOURNAL OF ENDOCRINOLOGY )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2015 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22CARDIOVASCULAR-DISEASE%22">CARDIOVASCULAR-DISEASE</searchLink><br /><searchLink fieldCode="DE" term="%22FIBRINOPEPTIDE-A%22">FIBRINOPEPTIDE-A</searchLink><br /><searchLink fieldCode="DE" term="%22RISK-FACTORS%22">RISK-FACTORS</searchLink><br /><searchLink fieldCode="DE" term="%22BIOMARKERS%22">BIOMARKERS</searchLink><br /><searchLink fieldCode="DE" term="%22DISCOVERY%22">DISCOVERY</searchLink><br /><searchLink fieldCode="DE" term="%22FIBRINOGEN%22">FIBRINOGEN</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEOMICS%22">PROTEOMICS</searchLink><br /><searchLink fieldCode="DE" term="%22MELLITUS%22">MELLITUS</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER%22">CANCER</searchLink><br /><searchLink fieldCode="DE" term="%22HEART%22">HEART</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => Objectives. We aim to explore urinary biomarkers that could monitor CAD in type 2 diabetic patients. Materials and Methods. Urine samples from two groups, twenty-eight type 2 diabetic patients with coexisting CAD and thirty type 2 diabetic patients without CAD, were purified by MB-WCX and then analyzed by MALDI-TOF-MS. Subsequently, we compared the urinary peptide signatures of the two groups by use of ClinProTools2.1 and evaluated the potential ability of the differently expressed peptides to distinguish type 2 diabetic patients with coexisting CAD from type 2 diabetic patients without CAD by ROC analysis. Finally, the differently expressed peptides were identified by nanoliquid chromatography-tandem mass spectrometry. Results. There were six differently expressed peptides (m/z 1305.2, 1743.9, 2184.9, 2756.1, 3223.2, and 6196.1) between the two groups of subjects, and they were identified as fragments of isoform 1 of fibrinogen alpha chain precursor, prothrombin precursor, and interalpha-trypsin inhibitor heavy chain H4. The diagnostic efficacy of m/z 2756.1 and m/z 3223.2 was better than the other peptides. Area under ROC of the m/z 2756.1, and m/z 3223.2 was 0.98 and 0.93, respectively. Conclusions. These urinary peptides are potential urinary biomarkers for monitoring of type 2 diabetic patients with CAD. ; Capital Health Research and Development of Special [2011-2008-02]; National Key Technology R&D Program: Key technology and application research of pre-pregnacy eugenics [2013BAI12B01-4] ; SCI(E) ; PubMed ; ARTICLE ; mzhang99@aliyun.com ; 758402 ; 2015 )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1687-8337<br />1687-8345 )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.2015.; 1302773; http://hdl.handle.net/20.500.11897/419235; WOS:000355463600001 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1155/2015/758402 )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/20.500.11897/419235<br />https://doi.org/10.1155/2015/758402<br />https://hdl.handle.net/20.500.11897/419235 )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.F4DA55F3 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1155/2015/758402 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => CARDIOVASCULAR-DISEASE [Type] => general ) [1] => Array ( [SubjectFull] => FIBRINOPEPTIDE-A [Type] => general ) [2] => Array ( [SubjectFull] => RISK-FACTORS [Type] => general ) [3] => Array ( [SubjectFull] => BIOMARKERS [Type] => general ) [4] => Array ( [SubjectFull] => DISCOVERY [Type] => general ) [5] => Array ( [SubjectFull] => FIBRINOGEN [Type] => general ) [6] => Array ( [SubjectFull] => PROTEOMICS [Type] => general ) [7] => Array ( [SubjectFull] => MELLITUS [Type] => general ) [8] => Array ( [SubjectFull] => CANCER [Type] => general ) [9] => Array ( [SubjectFull] => HEART [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fu, Guangzhen ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hu, Mei ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Chu, Lina ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Zhang, Man ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Zhang, M (reprint author), Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China. ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China. ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China. ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2015 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 16878337 ) [1] => Array ( [Type] => issn-print [Value] => 16878345 ) [2] => Array ( [Type] => issn-locals [Value] => edsbas ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => SCI ; PubMed [Type] => main ) ) ) ) ) ) )
IllustrationInfo