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Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases

التفاصيل البيبلوغرافية
العنوان: Placental growth factor and its potential role in diabetic retinopathy and other ocular neovascular diseases
المؤلفون: Nguyen, Q. D. and De Falco, S. and Behar-Cohen, F. and Lam, W. -C. and Li, X. and Reichhart, N. and Ricci, F. and Pluim, J. and Li, W. W. Nguyen, QD, De Falco, S, Behar-Cohen, F, Lam, WC, Li, X, Reichhart, N, Ricci, F, Pluim, J, Li, WW
المساهمون: Nguyen, Q. D., Adf, S., Ab, F., Al, W. -C., Al, X., Ar, N., Ar, F., Ap, J., Al, W. W., N, Qd, De Falco, S, Behar-Cohen, F, Lam, W, Li, X, Reichhart, N, Ricci, F, Pluim, J, Li, W
بيانات النشر: Blackwell Publishing Ltd
سنة النشر: 2018
المجموعة: Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca
مصطلحات موضوعية: aflibercept, bevacizumab, placental growth factor, ranibizumab, vasculotropin A, vasculotropin B, vasculotropin inhibitor, vasculotropin receptor 1, vasculotropin receptor 2, age related macular degeneration, clinical outcome, clinical research, comparative effectivene, diabetic macular edema, diabetic retinopathy, drug efficacy, drug safety, drug targeting, eye disease, gold standard, heart infarction, human, microangiopathy, nonhuman, ocular neovascular disease, priority journal, protein binding, protein domain, protein function, protein synthesi
الوصف: The role of vascular endothelial growth factor (VEGF), including in retinal vascular diseases, has been well studied, and pharmacological blockade of VEGF is the gold standard of treatment for neovascular age-related macular degeneration, retinal vein occlusion and diabetic macular oedema. Placental growth factor (PGF, previously known as PlGF), a homologue of VEGF, is a multifunctional peptide associated with angiogenesis-dependent pathologies in the eye and non-ocular conditions. Animal studies using genetic modification and pharmacological treatment have demonstrated a mechanistic role for PGF in pathological angiogenesis. Inhibition decreases neovascularization and microvascular abnormalities across different models, including oxygen-induced retinopathy, laser-induced choroidal neovascularization and in diabetic mice exhibiting retinopathies. High levels of PGF have been found in the vitreous of patients with diabetic retinopathy. Despite these strong animal data, the exact role of PGF in pathological angiogenesis in retinal vascular diseases remains to be defined, and the benefits of PGF-specific inhibition in humans with retinal neovascular diseases and macular oedema remain controversial. Comparative effectiveness research studies in patients with diabetic retinal disease have shown that treatment that inhibits both VEGF and PGF may provide superior outcomes in certain patients compared with treatment that inhibits only VEGF. This review summarizes current knowledge of PGF, including its relationship to VEGF and its role in pathological angiogenesis in retinal diseases, and identifies some key unanswered questions about PGF that can serve as a pathway for future basic, translational and clinical research. © 2016 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation and European Association for Vision & Eye Research.
نوع الوثيقة: article in journal/newspaper
اللغة: English
العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000423066600001; volume:96; issue:1; firstpage:e1; lastpage:e9; journal:ACTA OPHTHALMOLOGICA; http://hdl.handle.net/2108/242449Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85006078289; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85006078289&doi=10.1111/aos.13325&partnerID=40&md5=87503c4e9fdcd0cfe2727cf7bffee5a0Test
DOI: 10.1111/aos.13325
DOI: 10.1111/aos.13325&partnerID=40&md5=87503c4e9fdcd0cfe2727cf7bffee5a0
الإتاحة: https://doi.org/10.1111/aos.13325Test
http://hdl.handle.net/2108/242449Test
رقم الانضمام: edsbas.F1C75B88
قاعدة البيانات: BASE
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