دورية أكاديمية
Bioactivity of Biosilica Obtained From North Atlantic Deep-Sea Sponges
العنوان: | Bioactivity of Biosilica Obtained From North Atlantic Deep-Sea Sponges |
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المؤلفون: | Dudik, Olesia, Amorim, Sara, Xavier, Joana R., Rapp, Hans Tore, Silva, Tiago H., Pires, Ricardo A., Reis, Rui L. |
المساهمون: | Horizon 2020 Framework Programme |
المصدر: | Frontiers in Marine Science ; volume 8 ; ISSN 2296-7745 |
بيانات النشر: | Frontiers Media SA |
سنة النشر: | 2021 |
المجموعة: | Frontiers (Publisher - via CrossRef) |
مصطلحات موضوعية: | Ocean Engineering, Water Science and Technology, Aquatic Science, Global and Planetary Change, Oceanography |
الوصف: | Demosponges are a well-known source of a plethora of bioactive compounds. In particular, they are able to form a skeleton by direct deposition of silica in a process catalyzed by silicatein. Herein, we isolated biosilicas from five different Atlantic deep-sea sponges Geodia atlantica (GA), Geodia barretti (GB), Stelletta normani (SN), Axinella infundibuliformis (AI), and Phakellia ventilabrum (PV) to explore the bioactivity and osteogenic capacity of its silica-based materials. We chemically characterized the isolated biosilicas and evaluated them for their bioactivity to deposit Ca and P on their surface (by immersion in simulated body fluid, SBF). GB-, SN-, AI-, and PV-based biosilicas did not generate a stable calcium phosphate (CaP) layer over time in the presence of SBF, however, the GA-derived one was able to form a CaP surface layer (at a Ca/P ratio of ∼1.7, similar to the one observed for hydroxyapatite), that was stable during the 28 days of testing. In addition, no cytotoxicity toward L929 and SaOs2 cells was observed for the GA-based biosilica up to a concentration of 10 mg/mL. Overall, the GA-based biosilica presents the characteristics to be used in the development of biomaterials for bone tissue engineering (BTE). |
نوع الوثيقة: | article in journal/newspaper |
اللغة: | unknown |
DOI: | 10.3389/fmars.2021.637810 |
DOI: | 10.3389/fmars.2021.637810/full |
الإتاحة: | https://doi.org/10.3389/fmars.2021.637810Test |
حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
رقم الانضمام: | edsbas.E6B60A |
قاعدة البيانات: | BASE |
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