دورية أكاديمية
Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors
| العنوان: | Association between in-ICU red blood cells transfusion and 1-year mortality in ICU survivors |
|---|---|
| المؤلفون: | Blet, Alice, McNeil, Joel B., Josse, Julie, Cholley, Bernard, Cinotti, Raphaël, Cotter, Gad, Dauvergne, Agnès, Davison, Beth, Duarte, Kévin, Duranteau, Jacques, Fournier, Marie-Céline, Gayat, Etienne, Jaber, Samir, Lasocki, Sigismond, Merkling, Thomas, Peoc’h, Katell, Mayer, Imke, Sadoune, Malha, Laterre, Pierre-François, Sonneville, Romain, Ware, Lorraine, Mebazaa, Alexandre, Kimmoun, Antoine |
| المصدر: | Crit Care |
| بيانات النشر: | BioMed Central BMC HAL CCSD |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Research, demo, stat |
| الوصف: | BACKGROUND: Impact of in-ICU transfusion on long-term outcomes remains unknown. The purpose of this study was to assess in critical-care survivors the association between in-ICU red blood cells transfusion and 1-year mortality. METHODS: FROG-ICU, a multicenter European study enrolling all-comers critical care patients was analyzed (n = 1551). Association between red blood cells transfusion administered in intensive care unit and 1-year mortality in critical care survivors was analyzed using an augmented inverse probability of treatment weighting-augmented inverse probability of censoring weighting method to control confounders. RESULTS: Among the 1551 ICU-survivors, 42% received at least one unit of red blood cells while in intensive care unit. Patients in the transfusion group had greater severity scores than those in the no-transfusion group. According to unweighted analysis, 1-year post-critical care mortality was greater in the transfusion group compared to the no-transfusion group (hazard ratio (HR) 1.78, 95% CI 1.45–2.16). Weighted analyses including 40 confounders, showed that transfusion remained associated with a higher risk of long-term mortality (HR 1.21, 95% CI 1.06–1.46). CONCLUSIONS: Our results suggest a high incidence of in-ICU RBC transfusion and that in-ICU transfusion is associated with a higher 1-year mortality among in-ICU survivors. Trial registration (NCT01367093; Registered 6 June 2011). GRAPHIC ABSTRACT: [Image: see text] SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13054-022-04171-1. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547456Test/ |
| الإتاحة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9547456Test/ |
| حقوق: | undefined |
| رقم الانضمام: | edsbas.E4D721D3 |
| قاعدة البيانات: | BASE |
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