دورية أكاديمية
أعرض في EDS

Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.

التفاصيل البيبلوغرافية
العنوان: Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.
المؤلفون: Jakubowska, A, Rozkrut, D, Antoniou, A, Hamann, U, Scott, R J, McGuffog, L, Healy, S, Sinilnikova, O M, Rennert, G, Lejbkowicz, F, Flugelman, A, Andrulis, I L, Glendon, G, Ozcelik, H, Thomassen, M, Paligo, M, Aretini, P, Kantala, J, Aroer, B, von Wachenfeldt, A, Liljegren, A, Loman, N, Herbst, K, Kristoffersson, U, Rosenquist, R, Karlsson, P, Stenmark-Askmalm, M, Melin, B, Nathanson, K L, Domchek, S M, Byrski, T, Huzarski, T, Gronwald, J, Menkiszak, J, Cybulski, C, Serrano, P, Osorio, A, Cajal, T R, Tsitlaidou, M, Benítez, J, Gilbert, M, Rookus, M, Aalfs, C M, Kluijt, I, Boessenkool-Pape, J L, Meijers-Heijboer, H E J, Oosterwijk, J C, van Asperen, C J, Blok, M J, Nelen, M R, van den Ouweland, A M W, Seynaeve, C, van der Luijt, R B, Devilee, P, Easton, D F, Peock, S, Frost, D, Platte, R, Ellis, S D, Fineberg, E, Evans, D G, Lalloo, F, Eeles, R, Jacobs, C, Adlard, J, Davidson, R, Eccles, D, Cole, T, Cook, J, Godwin, A, Bove, B, Stoppa-Lyonnet, D, Caux-Moncoutier, V, Belotti, M, Tirapo, C, Mazoyer, S, Barjhoux, L, Boutry-Kryza, N, Pujol, P, Coupier, I, Peyrat, J-P, Vennin, P, Muller, D, Fricker, J-P, Venat-Bouvet, L, Jóhannsson, Óskar Þór, Isaacs, C, Schmutzler, R, Wappenschmidt, B, Meindl, A, Arnold, N, Varon-Mateeva, R, Niederacher, D, Sutter, C, Deissler, H, Preisler-Adams, S, Simard, J, Soucy, P, Durocher, F, Chenevix-Trench, G, Beesley, J, Chen, X, Rebbeck, T, Couch, F, Wang, X, Lindor, N, Fredericksen, Z, Pankratz, V S, Peterlongo, P, Bonanni, B, Fortuzzi, S, Peissel, B, Szabo, C, Mai, P L, Loud, J T, Lubinski, J
المساهمون: Cancer Center, Landspitali - The National University Hospital of Iceland
سنة النشر: 2012
المجموعة: Opin vísindi (Iceland)
مصطلحات موضوعية: Breast Neoplasms, Female, Genes, BRCA1, BRCA2, Genetic Predisposition to Disease, Heterozygote, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Mutation, Ovarian Neoplasms, Polymorphism, Genetic, Repressor Proteins, Risk
الوصف: The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. To evaluate the potential role of genetic variants within PHB and MTHFR in breast and ovarian cancer risk, 4102 BRCA1 and 2093 BRCA2 mutation carriers, and 6211 BRCA1 and 2902 BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) were genotyped for the PHB 1630 C>T (rs6917) polymorphism and the MTHFR 677 C>T (rs1801133) polymorphism, respectively. There was no evidence of association between the PHB 1630 C>T and MTHFR 677 C>T polymorphisms with either disease for BRCA1 or BRCA2 mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that BRCA1 mutation carriers who had the rare homozygote genotype (TT) of the PHB 1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1.50, 95%CI 1.10-2.04 and HR 2.16, 95%CI 1.24-3.76, respectively). However, there was no evidence of association under a multiplicative model for the effect of each minor allele. The PHB 1630TT genotype may modify breast and ovarian cancer risks in BRCA1 mutation carriers. This association need to be evaluated in larger series of BRCA1 mutation carriers. ; Peer reviewed
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1532-1827
العلاقة: British Journal of Cancer; (); http://dx.doi.org/10.1038/bjc.2012.160Test; http://www.nature.com/bjc/journal/vaop/ncurrent/abs/bjc2012160a.htmlTest; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388557Test/; Jakubowska , A , Rozkrut , D , Antoniou , A , Hamann , U , Scott , R J , McGuffog , L , Healy , S , Sinilnikova , O M , Rennert , G , Lejbkowicz , F , Flugelman , A , Andrulis , I L , Glendon , G , Ozcelik , H , Thomassen , M , Paligo , M , Aretini , P , Kantala , J , Aroer , B , von Wachenfeldt , A , Liljegren , A , Loman , N , Herbst , K , Kristoffersson , U , Rosenquist , R , Karlsson , P , Stenmark-Askmalm , M , Melin , B , Nathanson , K L , Domchek , S M , Byrski , T , Huzarski , T , Gronwald , J , Menkiszak , J , Cybulski , C , Serrano , P , Osorio , A , Cajal , T R , Tsitlaidou , M , Benítez , J , Gilbert , M , Rookus , M , Aalfs , C M , Kluijt , I , Boessenkool-Pape , J L , Meijers-Heijboer , H E J , Oosterwijk , J C , van Asperen , C J , Blok , M J , Nelen , M R , van den Ouweland , A M W , Seynaeve , C , van der Luijt , R B , Devilee , P , Easton , D F , Peock , S , Frost , D , Platte , R , Ellis , S D , Fineberg , E , Evans , D G , Lalloo , F , Eeles , R , Jacobs , C , Adlard , J , Davidson , R , Eccles , D , Cole , T , Cook , J , Godwin , A , Bove , B , Stoppa-Lyonnet , D , Caux-Moncoutier , V , Belotti , M , Tirapo , C , Mazoyer , S , Barjhoux , L , Boutry-Kryza , N , Pujol , P , Coupier , I , Peyrat , J-P , Vennin , P , Muller , D , Fricker , J-P , Venat-Bouvet , L , Jóhannsson , Ó Þ , Isaacs , C , Schmutzler , R , Wappenschmidt , B , Meindl , A , Arnold , N , Varon-Mateeva , R , Niederacher , D , Sutter , C , Deissler , H , Preisler-Adams , S , Simard , J , Soucy , P , Durocher , F , Chenevix-Trench , G , Beesley , J , Chen , X , Rebbeck , T , Couch , F , Wang , X , Lindor , N , Fredericksen , Z , Pankratz , V S , Peterlongo , P , Bonanni , B , Fortuzzi , S , Peissel , B , Szabo , C , Mai , P L , Loud , J T & Lubinski , J 2012 , ' Association of PHB 1630 C >T and MTHFR 677 C >T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. ' , British Journal of Cancer . https://doi.org/10.1038/bjc.2012.160Test; f87c7a18-fc1f-4a2f-8c71-ac28bc39253e; researchoutputwizard: hdl.handle.net/2336/299869; 84862017252; https://hdl.handle.net/20.500.11815/3651Test
DOI: 10.1038/bjc.2012.160
الإتاحة: https://doi.org/20.500.11815/3651Test
https://doi.org/10.1038/bjc.2012.160Test
https://hdl.handle.net/20.500.11815/3651Test
حقوق: info:eu-repo/semantics/openAccess
رقم الانضمام: edsbas.E0EB7177
قاعدة البيانات: BASE
ResultId 1
Header edsbas
BASE
edsbas.E0EB7177
844
3
Academic Journal
academicJournal
843.984313964844
PLink https://search.ebscohost.com/login.aspx?direct=true&site=eds-live&scope=site&db=edsbas&AN=edsbas.E0EB7177&custid=s6537998&authtype=sso
FullText Array ( [Availability] => 0 )
Array ( [0] => Array ( [Url] => https://doi.org/20.500.11815/3651# [Name] => EDS - BASE [Category] => fullText [Text] => View record in BASE [MouseOverText] => View record in BASE ) [1] => Array ( [Url] => https://resolver.ebscohost.com/openurl?custid=s6537998&groupid=main&authtype=ip,guest&sid=EBSCO:edsbas&genre=article&issn=15321827&ISBN=&volume=&issue=&date=20120101&spage=&pages=&title=Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study.&atitle=Association%20of%20PHB%201630%20C%3ET%20and%20MTHFR%20677%20C%3ET%20polymorphisms%20with%20breast%20and%20ovarian%20cancer%20risk%20in%20BRCA1%2F2%20mutation%20carriers%3A%20results%20from%20a%20multicenter%20study.&id=DOI:10.1038/bjc.2012.160 [Name] => Full Text Finder (s6537998api) [Category] => fullText [Text] => Full Text Finder [Icon] => https://imageserver.ebscohost.com/branding/images/FTF.gif [MouseOverText] => Full Text Finder ) )
Items Array ( [Name] => Title [Label] => Title [Group] => Ti [Data] => Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. )
Array ( [Name] => Author [Label] => Authors [Group] => Au [Data] => <searchLink fieldCode="AR" term="%22Jakubowska%2C+A%22">Jakubowska, A</searchLink><br /><searchLink fieldCode="AR" term="%22Rozkrut%2C+D%22">Rozkrut, D</searchLink><br /><searchLink fieldCode="AR" term="%22Antoniou%2C+A%22">Antoniou, A</searchLink><br /><searchLink fieldCode="AR" term="%22Hamann%2C+U%22">Hamann, U</searchLink><br /><searchLink fieldCode="AR" term="%22Scott%2C+R+J%22">Scott, R J</searchLink><br /><searchLink fieldCode="AR" term="%22McGuffog%2C+L%22">McGuffog, L</searchLink><br /><searchLink fieldCode="AR" term="%22Healy%2C+S%22">Healy, S</searchLink><br /><searchLink fieldCode="AR" term="%22Sinilnikova%2C+O+M%22">Sinilnikova, O M</searchLink><br /><searchLink fieldCode="AR" term="%22Rennert%2C+G%22">Rennert, G</searchLink><br /><searchLink fieldCode="AR" term="%22Lejbkowicz%2C+F%22">Lejbkowicz, F</searchLink><br /><searchLink fieldCode="AR" term="%22Flugelman%2C+A%22">Flugelman, A</searchLink><br /><searchLink fieldCode="AR" term="%22Andrulis%2C+I+L%22">Andrulis, I L</searchLink><br /><searchLink fieldCode="AR" term="%22Glendon%2C+G%22">Glendon, G</searchLink><br /><searchLink fieldCode="AR" term="%22Ozcelik%2C+H%22">Ozcelik, H</searchLink><br /><searchLink fieldCode="AR" term="%22Thomassen%2C+M%22">Thomassen, M</searchLink><br /><searchLink fieldCode="AR" term="%22Paligo%2C+M%22">Paligo, M</searchLink><br /><searchLink fieldCode="AR" term="%22Aretini%2C+P%22">Aretini, P</searchLink><br /><searchLink fieldCode="AR" term="%22Kantala%2C+J%22">Kantala, J</searchLink><br /><searchLink fieldCode="AR" term="%22Aroer%2C+B%22">Aroer, B</searchLink><br /><searchLink fieldCode="AR" term="%22von+Wachenfeldt%2C+A%22">von Wachenfeldt, A</searchLink><br /><searchLink fieldCode="AR" term="%22Liljegren%2C+A%22">Liljegren, A</searchLink><br /><searchLink fieldCode="AR" term="%22Loman%2C+N%22">Loman, N</searchLink><br /><searchLink fieldCode="AR" term="%22Herbst%2C+K%22">Herbst, K</searchLink><br /><searchLink fieldCode="AR" term="%22Kristoffersson%2C+U%22">Kristoffersson, U</searchLink><br /><searchLink fieldCode="AR" term="%22Rosenquist%2C+R%22">Rosenquist, R</searchLink><br /><searchLink fieldCode="AR" term="%22Karlsson%2C+P%22">Karlsson, P</searchLink><br /><searchLink fieldCode="AR" term="%22Stenmark-Askmalm%2C+M%22">Stenmark-Askmalm, M</searchLink><br /><searchLink fieldCode="AR" term="%22Melin%2C+B%22">Melin, B</searchLink><br /><searchLink fieldCode="AR" term="%22Nathanson%2C+K+L%22">Nathanson, K L</searchLink><br /><searchLink fieldCode="AR" term="%22Domchek%2C+S+M%22">Domchek, S M</searchLink><br /><searchLink fieldCode="AR" term="%22Byrski%2C+T%22">Byrski, T</searchLink><br /><searchLink fieldCode="AR" term="%22Huzarski%2C+T%22">Huzarski, T</searchLink><br /><searchLink fieldCode="AR" term="%22Gronwald%2C+J%22">Gronwald, J</searchLink><br /><searchLink fieldCode="AR" term="%22Menkiszak%2C+J%22">Menkiszak, J</searchLink><br /><searchLink fieldCode="AR" term="%22Cybulski%2C+C%22">Cybulski, C</searchLink><br /><searchLink fieldCode="AR" term="%22Serrano%2C+P%22">Serrano, P</searchLink><br /><searchLink fieldCode="AR" term="%22Osorio%2C+A%22">Osorio, A</searchLink><br /><searchLink fieldCode="AR" term="%22Cajal%2C+T+R%22">Cajal, T R</searchLink><br /><searchLink fieldCode="AR" term="%22Tsitlaidou%2C+M%22">Tsitlaidou, M</searchLink><br /><searchLink fieldCode="AR" term="%22Benítez%2C+J%22">Benítez, J</searchLink><br /><searchLink fieldCode="AR" term="%22Gilbert%2C+M%22">Gilbert, M</searchLink><br /><searchLink fieldCode="AR" term="%22Rookus%2C+M%22">Rookus, M</searchLink><br /><searchLink fieldCode="AR" term="%22Aalfs%2C+C+M%22">Aalfs, C M</searchLink><br /><searchLink fieldCode="AR" term="%22Kluijt%2C+I%22">Kluijt, I</searchLink><br /><searchLink fieldCode="AR" term="%22Boessenkool-Pape%2C+J+L%22">Boessenkool-Pape, J L</searchLink><br /><searchLink fieldCode="AR" term="%22Meijers-Heijboer%2C+H+E+J%22">Meijers-Heijboer, H E J</searchLink><br /><searchLink fieldCode="AR" term="%22Oosterwijk%2C+J+C%22">Oosterwijk, J C</searchLink><br /><searchLink fieldCode="AR" term="%22van+Asperen%2C+C+J%22">van Asperen, C J</searchLink><br /><searchLink fieldCode="AR" term="%22Blok%2C+M+J%22">Blok, M J</searchLink><br /><searchLink fieldCode="AR" term="%22Nelen%2C+M+R%22">Nelen, M R</searchLink><br /><searchLink fieldCode="AR" term="%22van+den+Ouweland%2C+A+M+W%22">van den Ouweland, A M W</searchLink><br /><searchLink fieldCode="AR" term="%22Seynaeve%2C+C%22">Seynaeve, C</searchLink><br /><searchLink fieldCode="AR" term="%22van+der+Luijt%2C+R+B%22">van der Luijt, R B</searchLink><br /><searchLink fieldCode="AR" term="%22Devilee%2C+P%22">Devilee, P</searchLink><br /><searchLink fieldCode="AR" term="%22Easton%2C+D+F%22">Easton, D F</searchLink><br /><searchLink fieldCode="AR" term="%22Peock%2C+S%22">Peock, S</searchLink><br /><searchLink fieldCode="AR" term="%22Frost%2C+D%22">Frost, D</searchLink><br /><searchLink fieldCode="AR" term="%22Platte%2C+R%22">Platte, R</searchLink><br /><searchLink fieldCode="AR" term="%22Ellis%2C+S+D%22">Ellis, S D</searchLink><br /><searchLink fieldCode="AR" term="%22Fineberg%2C+E%22">Fineberg, E</searchLink><br /><searchLink fieldCode="AR" term="%22Evans%2C+D+G%22">Evans, D G</searchLink><br /><searchLink fieldCode="AR" term="%22Lalloo%2C+F%22">Lalloo, F</searchLink><br /><searchLink fieldCode="AR" term="%22Eeles%2C+R%22">Eeles, R</searchLink><br /><searchLink fieldCode="AR" term="%22Jacobs%2C+C%22">Jacobs, C</searchLink><br /><searchLink fieldCode="AR" term="%22Adlard%2C+J%22">Adlard, J</searchLink><br /><searchLink fieldCode="AR" term="%22Davidson%2C+R%22">Davidson, R</searchLink><br /><searchLink fieldCode="AR" term="%22Eccles%2C+D%22">Eccles, D</searchLink><br /><searchLink fieldCode="AR" term="%22Cole%2C+T%22">Cole, T</searchLink><br /><searchLink fieldCode="AR" term="%22Cook%2C+J%22">Cook, J</searchLink><br /><searchLink fieldCode="AR" term="%22Godwin%2C+A%22">Godwin, A</searchLink><br /><searchLink fieldCode="AR" term="%22Bove%2C+B%22">Bove, B</searchLink><br /><searchLink fieldCode="AR" term="%22Stoppa-Lyonnet%2C+D%22">Stoppa-Lyonnet, D</searchLink><br /><searchLink fieldCode="AR" term="%22Caux-Moncoutier%2C+V%22">Caux-Moncoutier, V</searchLink><br /><searchLink fieldCode="AR" term="%22Belotti%2C+M%22">Belotti, M</searchLink><br /><searchLink fieldCode="AR" term="%22Tirapo%2C+C%22">Tirapo, C</searchLink><br /><searchLink fieldCode="AR" term="%22Mazoyer%2C+S%22">Mazoyer, S</searchLink><br /><searchLink fieldCode="AR" term="%22Barjhoux%2C+L%22">Barjhoux, L</searchLink><br /><searchLink fieldCode="AR" term="%22Boutry-Kryza%2C+N%22">Boutry-Kryza, N</searchLink><br /><searchLink fieldCode="AR" term="%22Pujol%2C+P%22">Pujol, P</searchLink><br /><searchLink fieldCode="AR" term="%22Coupier%2C+I%22">Coupier, I</searchLink><br /><searchLink fieldCode="AR" term="%22Peyrat%2C+J-P%22">Peyrat, J-P</searchLink><br /><searchLink fieldCode="AR" term="%22Vennin%2C+P%22">Vennin, P</searchLink><br /><searchLink fieldCode="AR" term="%22Muller%2C+D%22">Muller, D</searchLink><br /><searchLink fieldCode="AR" term="%22Fricker%2C+J-P%22">Fricker, J-P</searchLink><br /><searchLink fieldCode="AR" term="%22Venat-Bouvet%2C+L%22">Venat-Bouvet, L</searchLink><br /><searchLink fieldCode="AR" term="%22Jóhannsson%2C+Óskar+Þór%22">Jóhannsson, Óskar Þór</searchLink><br /><searchLink fieldCode="AR" term="%22Isaacs%2C+C%22">Isaacs, C</searchLink><br /><searchLink fieldCode="AR" term="%22Schmutzler%2C+R%22">Schmutzler, R</searchLink><br /><searchLink fieldCode="AR" term="%22Wappenschmidt%2C+B%22">Wappenschmidt, B</searchLink><br /><searchLink fieldCode="AR" term="%22Meindl%2C+A%22">Meindl, A</searchLink><br /><searchLink fieldCode="AR" term="%22Arnold%2C+N%22">Arnold, N</searchLink><br /><searchLink fieldCode="AR" term="%22Varon-Mateeva%2C+R%22">Varon-Mateeva, R</searchLink><br /><searchLink fieldCode="AR" term="%22Niederacher%2C+D%22">Niederacher, D</searchLink><br /><searchLink fieldCode="AR" term="%22Sutter%2C+C%22">Sutter, C</searchLink><br /><searchLink fieldCode="AR" term="%22Deissler%2C+H%22">Deissler, H</searchLink><br /><searchLink fieldCode="AR" term="%22Preisler-Adams%2C+S%22">Preisler-Adams, S</searchLink><br /><searchLink fieldCode="AR" term="%22Simard%2C+J%22">Simard, J</searchLink><br /><searchLink fieldCode="AR" term="%22Soucy%2C+P%22">Soucy, P</searchLink><br /><searchLink fieldCode="AR" term="%22Durocher%2C+F%22">Durocher, F</searchLink><br /><searchLink fieldCode="AR" term="%22Chenevix-Trench%2C+G%22">Chenevix-Trench, G</searchLink><br /><searchLink fieldCode="AR" term="%22Beesley%2C+J%22">Beesley, J</searchLink><br /><searchLink fieldCode="AR" term="%22Chen%2C+X%22">Chen, X</searchLink><br /><searchLink fieldCode="AR" term="%22Rebbeck%2C+T%22">Rebbeck, T</searchLink><br /><searchLink fieldCode="AR" term="%22Couch%2C+F%22">Couch, F</searchLink><br /><searchLink fieldCode="AR" term="%22Wang%2C+X%22">Wang, X</searchLink><br /><searchLink fieldCode="AR" term="%22Lindor%2C+N%22">Lindor, N</searchLink><br /><searchLink fieldCode="AR" term="%22Fredericksen%2C+Z%22">Fredericksen, Z</searchLink><br /><searchLink fieldCode="AR" term="%22Pankratz%2C+V+S%22">Pankratz, V S</searchLink><br /><searchLink fieldCode="AR" term="%22Peterlongo%2C+P%22">Peterlongo, P</searchLink><br /><searchLink fieldCode="AR" term="%22Bonanni%2C+B%22">Bonanni, B</searchLink><br /><searchLink fieldCode="AR" term="%22Fortuzzi%2C+S%22">Fortuzzi, S</searchLink><br /><searchLink fieldCode="AR" term="%22Peissel%2C+B%22">Peissel, B</searchLink><br /><searchLink fieldCode="AR" term="%22Szabo%2C+C%22">Szabo, C</searchLink><br /><searchLink fieldCode="AR" term="%22Mai%2C+P+L%22">Mai, P L</searchLink><br /><searchLink fieldCode="AR" term="%22Loud%2C+J+T%22">Loud, J T</searchLink><br /><searchLink fieldCode="AR" term="%22Lubinski%2C+J%22">Lubinski, J</searchLink> )
Array ( [Name] => Author [Label] => Contributors [Group] => Au [Data] => Cancer Center<br />Landspitali - The National University Hospital of Iceland )
Array ( [Name] => DatePubCY [Label] => Publication Year [Group] => Date [Data] => 2012 )
Array ( [Name] => Subset [Label] => Collection [Group] => HoldingsInfo [Data] => Opin vísindi (Iceland) )
Array ( [Name] => Subject [Label] => Subject Terms [Group] => Su [Data] => <searchLink fieldCode="DE" term="%22Breast+Neoplasms%22">Breast Neoplasms</searchLink><br /><searchLink fieldCode="DE" term="%22Female%22">Female</searchLink><br /><searchLink fieldCode="DE" term="%22Genes%22">Genes</searchLink><br /><searchLink fieldCode="DE" term="%22BRCA1%22">BRCA1</searchLink><br /><searchLink fieldCode="DE" term="%22BRCA2%22">BRCA2</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic+Predisposition+to+Disease%22">Genetic Predisposition to Disease</searchLink><br /><searchLink fieldCode="DE" term="%22Heterozygote%22">Heterozygote</searchLink><br /><searchLink fieldCode="DE" term="%22Humans%22">Humans</searchLink><br /><searchLink fieldCode="DE" term="%22Methylenetetrahydrofolate+Reductase+%28NADPH2%29%22">Methylenetetrahydrofolate Reductase (NADPH2)</searchLink><br /><searchLink fieldCode="DE" term="%22Mutation%22">Mutation</searchLink><br /><searchLink fieldCode="DE" term="%22Ovarian+Neoplasms%22">Ovarian Neoplasms</searchLink><br /><searchLink fieldCode="DE" term="%22Polymorphism%22">Polymorphism</searchLink><br /><searchLink fieldCode="DE" term="%22Genetic%22">Genetic</searchLink><br /><searchLink fieldCode="DE" term="%22Repressor+Proteins%22">Repressor Proteins</searchLink><br /><searchLink fieldCode="DE" term="%22Risk%22">Risk</searchLink> )
Array ( [Name] => Abstract [Label] => Description [Group] => Ab [Data] => The variable penetrance of breast cancer in BRCA1/2 mutation carriers suggests that other genetic or environmental factors modify breast cancer risk. Two genes of special interest are prohibitin (PHB) and methylene-tetrahydrofolate reductase (MTHFR), both of which are important either directly or indirectly in maintaining genomic integrity. To evaluate the potential role of genetic variants within PHB and MTHFR in breast and ovarian cancer risk, 4102 BRCA1 and 2093 BRCA2 mutation carriers, and 6211 BRCA1 and 2902 BRCA2 carriers from the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA) were genotyped for the PHB 1630 C>T (rs6917) polymorphism and the MTHFR 677 C>T (rs1801133) polymorphism, respectively. There was no evidence of association between the PHB 1630 C>T and MTHFR 677 C>T polymorphisms with either disease for BRCA1 or BRCA2 mutation carriers when breast and ovarian cancer associations were evaluated separately. Analysis that evaluated associations for breast and ovarian cancer simultaneously showed some evidence that BRCA1 mutation carriers who had the rare homozygote genotype (TT) of the PHB 1630 C>T polymorphism were at increased risk of both breast and ovarian cancer (HR 1.50, 95%CI 1.10-2.04 and HR 2.16, 95%CI 1.24-3.76, respectively). However, there was no evidence of association under a multiplicative model for the effect of each minor allele. The PHB 1630TT genotype may modify breast and ovarian cancer risks in BRCA1 mutation carriers. This association need to be evaluated in larger series of BRCA1 mutation carriers. ; Peer reviewed )
Array ( [Name] => TypeDocument [Label] => Document Type [Group] => TypDoc [Data] => article in journal/newspaper )
Array ( [Name] => Language [Label] => Language [Group] => Lang [Data] => English )
Array ( [Name] => ISSN [Label] => ISSN [Group] => ISSN [Data] => 1532-1827 )
Array ( [Name] => NoteTitleSource [Label] => Relation [Group] => SrcInfo [Data] => British Journal of Cancer; (); http://dx.doi.org/10.1038/bjc.2012.160; http://www.nature.com/bjc/journal/vaop/ncurrent/abs/bjc2012160a.html; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3388557/; Jakubowska , A , Rozkrut , D , Antoniou , A , Hamann , U , Scott , R J , McGuffog , L , Healy , S , Sinilnikova , O M , Rennert , G , Lejbkowicz , F , Flugelman , A , Andrulis , I L , Glendon , G , Ozcelik , H , Thomassen , M , Paligo , M , Aretini , P , Kantala , J , Aroer , B , von Wachenfeldt , A , Liljegren , A , Loman , N , Herbst , K , Kristoffersson , U , Rosenquist , R , Karlsson , P , Stenmark-Askmalm , M , Melin , B , Nathanson , K L , Domchek , S M , Byrski , T , Huzarski , T , Gronwald , J , Menkiszak , J , Cybulski , C , Serrano , P , Osorio , A , Cajal , T R , Tsitlaidou , M , Benítez , J , Gilbert , M , Rookus , M , Aalfs , C M , Kluijt , I , Boessenkool-Pape , J L , Meijers-Heijboer , H E J , Oosterwijk , J C , van Asperen , C J , Blok , M J , Nelen , M R , van den Ouweland , A M W , Seynaeve , C , van der Luijt , R B , Devilee , P , Easton , D F , Peock , S , Frost , D , Platte , R , Ellis , S D , Fineberg , E , Evans , D G , Lalloo , F , Eeles , R , Jacobs , C , Adlard , J , Davidson , R , Eccles , D , Cole , T , Cook , J , Godwin , A , Bove , B , Stoppa-Lyonnet , D , Caux-Moncoutier , V , Belotti , M , Tirapo , C , Mazoyer , S , Barjhoux , L , Boutry-Kryza , N , Pujol , P , Coupier , I , Peyrat , J-P , Vennin , P , Muller , D , Fricker , J-P , Venat-Bouvet , L , Jóhannsson , Ó Þ , Isaacs , C , Schmutzler , R , Wappenschmidt , B , Meindl , A , Arnold , N , Varon-Mateeva , R , Niederacher , D , Sutter , C , Deissler , H , Preisler-Adams , S , Simard , J , Soucy , P , Durocher , F , Chenevix-Trench , G , Beesley , J , Chen , X , Rebbeck , T , Couch , F , Wang , X , Lindor , N , Fredericksen , Z , Pankratz , V S , Peterlongo , P , Bonanni , B , Fortuzzi , S , Peissel , B , Szabo , C , Mai , P L , Loud , J T & Lubinski , J 2012 , ' Association of PHB 1630 C >T and MTHFR 677 C >T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. ' , British Journal of Cancer . https://doi.org/10.1038/bjc.2012.160; f87c7a18-fc1f-4a2f-8c71-ac28bc39253e; researchoutputwizard: hdl.handle.net/2336/299869; 84862017252; https://hdl.handle.net/20.500.11815/3651 )
Array ( [Name] => DOI [Label] => DOI [Group] => ID [Data] => 10.1038/bjc.2012.160 )
Array ( [Name] => URL [Label] => Availability [Group] => URL [Data] => https://doi.org/20.500.11815/3651<br />https://doi.org/10.1038/bjc.2012.160<br />https://hdl.handle.net/20.500.11815/3651 )
Array ( [Name] => Copyright [Label] => Rights [Group] => Cpyrght [Data] => info:eu-repo/semantics/openAccess )
Array ( [Name] => AN [Label] => Accession Number [Group] => ID [Data] => edsbas.E0EB7177 )
RecordInfo Array ( [BibEntity] => Array ( [Identifiers] => Array ( [0] => Array ( [Type] => doi [Value] => 10.1038/bjc.2012.160 ) ) [Languages] => Array ( [0] => Array ( [Text] => English ) ) [Subjects] => Array ( [0] => Array ( [SubjectFull] => Breast Neoplasms [Type] => general ) [1] => Array ( [SubjectFull] => Female [Type] => general ) [2] => Array ( [SubjectFull] => Genes [Type] => general ) [3] => Array ( [SubjectFull] => BRCA1 [Type] => general ) [4] => Array ( [SubjectFull] => BRCA2 [Type] => general ) [5] => Array ( [SubjectFull] => Genetic Predisposition to Disease [Type] => general ) [6] => Array ( [SubjectFull] => Heterozygote [Type] => general ) [7] => Array ( [SubjectFull] => Humans [Type] => general ) [8] => Array ( [SubjectFull] => Methylenetetrahydrofolate Reductase (NADPH2) [Type] => general ) [9] => Array ( [SubjectFull] => Mutation [Type] => general ) [10] => Array ( [SubjectFull] => Ovarian Neoplasms [Type] => general ) [11] => Array ( [SubjectFull] => Polymorphism [Type] => general ) [12] => Array ( [SubjectFull] => Genetic [Type] => general ) [13] => Array ( [SubjectFull] => Repressor Proteins [Type] => general ) [14] => Array ( [SubjectFull] => Risk [Type] => general ) ) [Titles] => Array ( [0] => Array ( [TitleFull] => Association of PHB 1630 C>T and MTHFR 677 C>T polymorphisms with breast and ovarian cancer risk in BRCA1/2 mutation carriers: results from a multicenter study. [Type] => main ) ) ) [BibRelationships] => Array ( [HasContributorRelationships] => Array ( [0] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jakubowska, A ) ) ) [1] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rozkrut, D ) ) ) [2] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Antoniou, A ) ) ) [3] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Hamann, U ) ) ) [4] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Scott, R J ) ) ) [5] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => McGuffog, L ) ) ) [6] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Healy, S ) ) ) [7] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sinilnikova, O M ) ) ) [8] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rennert, G ) ) ) [9] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lejbkowicz, F ) ) ) [10] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Flugelman, A ) ) ) [11] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Andrulis, I L ) ) ) [12] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Glendon, G ) ) ) [13] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ozcelik, H ) ) ) [14] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Thomassen, M ) ) ) [15] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Paligo, M ) ) ) [16] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Aretini, P ) ) ) [17] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kantala, J ) ) ) [18] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Aroer, B ) ) ) [19] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => von Wachenfeldt, A ) ) ) [20] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Liljegren, A ) ) ) [21] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Loman, N ) ) ) [22] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Herbst, K ) ) ) [23] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kristoffersson, U ) ) ) [24] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rosenquist, R ) ) ) [25] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Karlsson, P ) ) ) [26] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Stenmark-Askmalm, M ) ) ) [27] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Melin, B ) ) ) [28] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nathanson, K L ) ) ) [29] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Domchek, S M ) ) ) [30] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Byrski, T ) ) ) [31] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Huzarski, T ) ) ) [32] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gronwald, J ) ) ) [33] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Menkiszak, J ) ) ) [34] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cybulski, C ) ) ) [35] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Serrano, P ) ) ) [36] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Osorio, A ) ) ) [37] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cajal, T R ) ) ) [38] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Tsitlaidou, M ) ) ) [39] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Benítez, J ) ) ) [40] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Gilbert, M ) ) ) [41] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rookus, M ) ) ) [42] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Aalfs, C M ) ) ) [43] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Kluijt, I ) ) ) [44] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Boessenkool-Pape, J L ) ) ) [45] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Meijers-Heijboer, H E J ) ) ) [46] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Oosterwijk, J C ) ) ) [47] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van Asperen, C J ) ) ) [48] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Blok, M J ) ) ) [49] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Nelen, M R ) ) ) [50] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van den Ouweland, A M W ) ) ) [51] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Seynaeve, C ) ) ) [52] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => van der Luijt, R B ) ) ) [53] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Devilee, P ) ) ) [54] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Easton, D F ) ) ) [55] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Peock, S ) ) ) [56] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Frost, D ) ) ) [57] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Platte, R ) ) ) [58] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Ellis, S D ) ) ) [59] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fineberg, E ) ) ) [60] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Evans, D G ) ) ) [61] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lalloo, F ) ) ) [62] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Eeles, R ) ) ) [63] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jacobs, C ) ) ) [64] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Adlard, J ) ) ) [65] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Davidson, R ) ) ) [66] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Eccles, D ) ) ) [67] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cole, T ) ) ) [68] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cook, J ) ) ) [69] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Godwin, A ) ) ) [70] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bove, B ) ) ) [71] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Stoppa-Lyonnet, D ) ) ) [72] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Caux-Moncoutier, V ) ) ) [73] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Belotti, M ) ) ) [74] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Tirapo, C ) ) ) [75] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mazoyer, S ) ) ) [76] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Barjhoux, L ) ) ) [77] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Boutry-Kryza, N ) ) ) [78] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pujol, P ) ) ) [79] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Coupier, I ) ) ) [80] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Peyrat, J-P ) ) ) [81] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Vennin, P ) ) ) [82] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Muller, D ) ) ) [83] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fricker, J-P ) ) ) [84] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Venat-Bouvet, L ) ) ) [85] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Jóhannsson, Óskar Þór ) ) ) [86] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Isaacs, C ) ) ) [87] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Schmutzler, R ) ) ) [88] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wappenschmidt, B ) ) ) [89] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Meindl, A ) ) ) [90] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Arnold, N ) ) ) [91] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Varon-Mateeva, R ) ) ) [92] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Niederacher, D ) ) ) [93] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Sutter, C ) ) ) [94] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Deissler, H ) ) ) [95] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Preisler-Adams, S ) ) ) [96] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Simard, J ) ) ) [97] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Soucy, P ) ) ) [98] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Durocher, F ) ) ) [99] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Chenevix-Trench, G ) ) ) [100] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Beesley, J ) ) ) [101] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Chen, X ) ) ) [102] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Rebbeck, T ) ) ) [103] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Couch, F ) ) ) [104] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Wang, X ) ) ) [105] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lindor, N ) ) ) [106] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fredericksen, Z ) ) ) [107] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Pankratz, V S ) ) ) [108] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Peterlongo, P ) ) ) [109] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Bonanni, B ) ) ) [110] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Fortuzzi, S ) ) ) [111] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Peissel, B ) ) ) [112] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Szabo, C ) ) ) [113] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Mai, P L ) ) ) [114] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Loud, J T ) ) ) [115] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Lubinski, J ) ) ) [116] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Cancer Center ) ) ) [117] => Array ( [PersonEntity] => Array ( [Name] => Array ( [NameFull] => Landspitali - The National University Hospital of Iceland ) ) ) ) [IsPartOfRelationships] => Array ( [0] => Array ( [BibEntity] => Array ( [Dates] => Array ( [0] => Array ( [D] => 01 [M] => 01 [Type] => published [Y] => 2012 ) ) [Identifiers] => Array ( [0] => Array ( [Type] => issn-print [Value] => 15321827 ) [1] => Array ( [Type] => issn-locals [Value] => edsbas ) [2] => Array ( [Type] => issn-locals [Value] => edsbas.oa ) ) ) ) ) ) )
IllustrationInfo